BIOPEP-UWM: Report

ID 10908
Name Neprilysin inhibitor
sequence
EA
Function:
Inhibitor of Neprilysin (EC 3.4.24.11) (MEROPS ID: M13.001)
 
Number of residues
2
Activity code
nep
Activity :
neprilysin inhibitor
Chemical mass 218.2066 Monoisotopic mass 218.0899
EC50 :
0.00 µM


Bibliographic data:
Authors
Moreno-Mariscal C., Carrera-Alvarado G., Mora L., Toldrá F.
Title
Neprilysin (NEP) and Angiotensin Converting Enzyme-I (ACE-I) inhibitory dipeptides from chicken carcass hydrolysates. LWT, 221, 117591, 2025
Year Source
2025 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(C)C(=O)O

InChI=1S/C8H14N2O5/c1-4(8(14)15)10-7(13)5(9)2-3-6(11)12/h4-5H,2-3,9H2,1H3,(H,10,13)(H,11,12)(H,14,15)/t4-,5-/m0/s1

InChIKey=JZDHUJAFXGNDSB-WHFBIAKZSA-N


Inhibitor of angiotensin I-converting enzyme (EC 3.4.15.1; MEROPS ID: M02-001) according to the BIOPEP-UWM database of bioactive peptides (ID 7623)
Inhibitor of alpha-glucosidase (EC 3.2.1.20) according to the BIOPEP-UWM database of bioactive peptides (ID 9650)

Umami peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 362)
Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 363)


Database reference:
ACToR: ID 21064-18-6

AHTPDB: ID 2997; 3032; 3046; 3071; 3255; 3359; 3427; 3472; 3555; 3836; 3897; 4397; 4542; 4696; 6610

BindingDB: ID 50169155

BioPepDB: ID biopep00162

BIOPEP-UWM database of bioactive peptides: ID 9650

BIOPEP-UWM database of sensory peptides and amino acids: ID 362; 363

BRENDA: Ligand Glu-Ala

CAS: ID 21064-18-6

ChEBI: ID 73849

ChemIDplus: ID 21064-18-6

ChEMBL: ID CHEMBL90074

ChemSpider: ID 5360636

CTD: 21064-18-6

EROP-Moscow: ID E24486

HMDB: ID HMDB0003764

J-GLOBAL: ID 200907083878894890

MeSH: Terms Glu-Ala, glutamylalanine

Metabolights: ID MTBLC73849

Metabolomics Workbench: ID 78776

Nikkaji: ID J150.577G

PubChem: ID 6992506

SATPdb: ID satpdb18482

SDBS: ID NMR-CDS-07-416

SureChEMBL: ID SCHEMBL751142

UniChem: ID 108627

Wikidata: ID Q27144175

ZINC: ID ZINC01576200