BIOPEP-UWM: Report

ID 10911
Name Neprilysin inhibitor
sequence
GE
Function:
Inhibitor of Neprilysin (EC 3.4.24.11) (MEROPS ID: M13.001)
 
Number of residues
2
Activity code
nep
Activity :
neprilysin inhibitor
Chemical mass 204.1801 Monoisotopic mass 204.0743
EC50 :
0.00 µM


Bibliographic data:
Authors
Moreno-Mariscal C., Carrera-Alvarado G., Mora L., Toldrá F.
Title
Neprilysin (NEP) and Angiotensin Converting Enzyme-I (ACE-I) inhibitory dipeptides from chicken carcass hydrolysates. LWT, 221, 117591, 2025
Year Source
2025 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: NCC(=O)N[C@@]([H])(CCC(=O)O)C(=O)O

InChI=1S/C7H12N2O5/c8-3-5(10)9-4(7(13)14)1-2-6(11)12/h4H,1-3,8H2,(H,9,10)(H,11,12)(H,13,14)/t4-/m0/s1

InChIKey=IEFJWDNGDZAYNZ-BYPYZUCNSA-N


Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the BIOPEP-UWM database of bioactive peptides (ID 7615); the ChEMBL database; the EROP-Moscow database; the PubChem database
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8781)
Inhibitor of citrulline uptake in yeasts according to the ChEMBL database; the PubChem database
Inhibitor of Dipeptidyl peptidase-III (DPP-III) (EC 3.4.14.4) (MEROPS ID: M49.001) according to the BIOPEP-UWM database of bioactive peptides (D 9487); the BRENDA database
Inhibitor of Glutamate carboxypeptidase (EC 3.4.17.11) (MEROPS ID: M20.001) according to the BIOPEP-UWM database of bioactive peptides (ID 10623); the BRENDA database
Inhibitor of Glutamate carboxypeptidase II (EC 3.4.17.21) (MEROPS ID: M28.010) according to the BIOPEP-UWM database of bioactive peptides (ID 10654); the BRENDA database

Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 137)


Database reference:
AHTPDB: ID 1474; 3043; 3247; 3425; 3814; 3917; 4409; 4520; 4689; 6601

BindingDB: ID 50188529

BioPepDB: ID biopep00330

BIOPEP-UWM database of bioactive peptides: ID 7615; 8781; 9487; 10623; 10654

BIOPEP-UWM database of sensory peptides and amino acids: ID 137

BRENDA: Ligand Gly-Glu

CAS: Registry No 7412-78-4

ChEBI: ID 73801

ChEMBL: ID CHEMBL314532

ChemIDplus: ID 007412784

ChemSpider ID: 89688

DFBP: ID DFBPACEI1631

ECHA: ID 231-019-4

EPA CompTox: ID DTXSID401314278

EROP-Moscow: ID E10387

J-GLOBAL: ID 200907069620514802

MeSH: Terms Gly-Glu; N-glycylglutamic acid

Metabolights: ID MTBLC73801

Nikkaji：ID J149.621B

PlantPepDB: ID PPepDB_53

PubChem: CID 99278

SATPdb: ID satpdb13269

SureChEMBL: ID SCHEMBL709721

UniChem: ID 314736

Wikidata: ID Q27144115

ZINC: ID ZINC02567986