BIOPEP-UWM: Report

ID 10913
Name Neprilysin inhibitor
sequence
GP
Function:
Inhibitor of Neprilysin (EC 3.4.24.11) (MEROPS ID: M13.001)
 
Number of residues
2
Activity code
nep
Activity :
neprilysin inhibitor
Chemical mass 172.1813 Monoisotopic mass 172.0845
EC50 :
0.00 µM


Bibliographic data:
Authors
Moreno-Mariscal C., Carrera-Alvarado G., Mora L., Toldrá F.
Title
Neprilysin (NEP) and Angiotensin Converting Enzyme-I (ACE-I) inhibitory dipeptides from chicken carcass hydrolysates. LWT, 221, 117591, 2025
Year Source
2025 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: C1C[C@H](N(C1)C(=O)CN)C(=O)O

InChI=1S/C7H12N2O3/c8-4-6(10)9-3-1-2-5(9)7(11)12/h5H,1-4,8H2,(H,11,12)/t5-/m0/s1

InChIKey=KZNQNBZMBZJQJO-YFKPBYRVSA-N


Inhibitor of dipeptidyl peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 3169);
Antithrombotic peptide according to the BIOPEP-UWM database of bioactive peptides (ID 3283);
Inhibitor of prolyl endopeptidase (EC 3.4.21.26) (MEROPS ID: S09.001) according to the BIOPEP-UWM database of bioactive peptides (ID 3461)
Regulator of the stomach mucosal membrane activity according to the BIOPEP-UWM database of bioactive peptides (ID 2753)
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the BIOPEP-UWM database of bioactive peptides (ID 7512)


Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids, the ChEMBL database; the EROP-Moscow database (ID E03695), the PubChem database


Database reference:
AHTPDB: ID 1391; 1392; 1420; 3413; 3489; 3614; 3795; 3840; 3930; 4434; 4501; 4694; 5151; 5426; 5642; 5677; 6111; 6163; 6522

BindingDB: ID 50169189

BioCyc: ID CPD-10814

BioPepDB: ID biopep00379

BIOPEP-UWM database of bioactive peptides ID: 2753; 3169; 3283; 3461; 7512

BIOPEP-UWM database of sensory peptides and amino acids: ID 17

BRENDA: Ligand Gly-Pro

CAS: Registry No 704-15-4

ChEBI: ID 70744

ChEMBL: ID CHEMBL80548

ChemSpider: ID 2282246

DFBP: ID DFBPANHY0599, DFBPACEI0680, DFBPACEI1689, DFBPACEI1707, DFBPACEI1782, DFBPANOX0687, DFBPANTH0035, DFBPDPIV0131, DFBPMUFU0152

ECHA: ID 211-880-2

EPA CompTox: ID DTXSID701016976

EROP-Moscow: ID E03695; E09223

FDA SRS: ID BJZ69WB3VD

FooDB: ID FDB022202

HMDB: ID HMDB0000721

J-GLOBAL: ID 200907097129168220

MarkerDB: ID MDB00000236

MBPDB: Peptide GP

MeSH: Terms Gly-Pro, glycyl-L-prolinę, glycylproline

Metabolights: ID MTBLC70744

Metabolomics Workbench: ID 78810

Nikkaji: ID J150.128C

PlanPepDB: ID PPepDB_2911

PubChem: ID 3013625

Rhea: ID 73779

SATPdb: ID satpdb20549

SureChEMBL: ID SCHEMBL155067

UNII: ID BJZ69WB3VD

Wikidata: ID Q27139057

ZINC: ID ZINC000001637972