BIOPEP-UWM: Report

ID 10916
Name Neprilysin inhibitor
sequence
VV
Function:
Inhibitor of Neprilysin (EC 3.4.24.11) (MEROPS ID: M13.001)
 
Number of residues
2
Activity code
nep
Activity :
neprilysin inhibitor
Chemical mass 216.2766 Monoisotopic mass 216.1469
EC50 :
0.00 µM


Bibliographic data:
Authors
Moreno-Mariscal C., Carrera-Alvarado G., Mora L., Toldrá F.
Title
Neprilysin (NEP) and Angiotensin Converting Enzyme-I (ACE-I) inhibitory dipeptides from chicken carcass hydrolysates. LWT, 221, 117591, 2025
Year Source
2025 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)O

InChI=1S/C10H20N2O3/c1-5(2)7(11)9(13)12-8(6(3)4)10(14)15/h5-8H,11H2,1-4H3,(H,12,13)(H,14,15)/t7-,8-/m0/s1

InChIKey=KRNYOVHEKOBTEF-YUMQZZPRSA-N


Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 3183)
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database
Inhibitor of tripeptidyl peptidase II (EC 3.4.14.10) (MEROPS ID: S08.090) according to the BIOPEP-UWM database of bioactive peptides (ID 10797)

Umami peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 259);
Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 328); the ChEMBL database; the PubChem database


Database reference:
ACToR: ID 41049-53-0

AHTPDB: ID 3849

BindingDB: ID 50188521

BIOPEP-UWM database of bioactive peptides: ID 3183, 10797

BIOPEP-UWM database of sensory peptides and amino acids: ID 259; 328

BRENDA: Ligand Val-Val

Cambridge Structural Database: ID 290258

CAS: Registry No 3918-94-3

ChEBI: ID 73704

ChEMBL: ID CHEMBL54552

ChemSpider: ID 96710

EPA DSSTox: ID DTXCID601387837

EROP-Moscow: ID E09237

FeptideDB: ID 3183

FooDB: ID FDB112141

HMDB: ID HMDB0029140

J-GLOBAL: ID 200907038164816513

MeSH:Terms L-valyl-L-valine; Val-Val; valylvaline

Metabolights: ID MTBLC73704

Metabolomics Workbench: ID 79055

MMDB: ID 3226.3

Nikkaji: ID J364.680G

PubChem: ID 107475

SATPdb: ID satpdb12649

SureChEMBL: ID SCHEMBL4582286

UniChem: ID 412126

Wikidata: Q27143934

ZINC: ID ZINC000001848346