BIOPEP-UWM: Report

ID 10917
Name Neprilysin inhibitor
sequence
RG
Function:
Inhibitor of Neprilysin (EC 3.4.24.11) (MEROPS ID: M13.001)
 
Number of residues
2
Activity code
nep
Activity :
neprilysin inhibitor
Chemical mass 231.2516 Monoisotopic mass 231.1328
EC50 :
0.00 µM


Bibliographic data:
Authors
Moreno-Mariscal C., Carrera-Alvarado G., Mora L., Toldrá F.
Title
Neprilysin (NEP) and Angiotensin Converting Enzyme-I (ACE-I) inhibitory dipeptides from chicken carcass hydrolysates. LWT, 221, 117591, 2025
Year Source
2025 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)O

InChI=1S/C8H17N5O3/c9-5(2-1-3-12-8(10)11)7(16)13-4-6(14)15/h5H,1-4,9H2,(H,13,16)(H,14,15)(H4,10,11,12)/t5-/m0/s1

InChIKey=XUUXCWCKKCZEAW-YFKPBYRVSA-N


Inhibitor of the angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database, the BIOPEP-UWM database of bioactive peptides (ID 9173), the EROP-Moscow database
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8882)
Inhibitor of citrulline uptake in yeasts according to the ChEMBL database; the PubChem database
Inhibitor of the Leucyltransferase (EC 2.3.2.6) according to the BIOPEP-UWM database of bioactive peptides (ID 10456)

Bitter peptide according to the BIOPEP database of sensory peptides and amino acids (ID 8)
Salty taste enhancing peptide according to the BIOPEP database of sensory peptides and amino acids (ID 422)


Database reference:
ACToR: ID 2418-67-9

AHTPDB: ID 1479; 5433; 5448

BindingDB: ID 50188522

BioPepDB: ID biopep01186

BIOPEP-UWM database of bioactive peptides: ID 8882, 9173, 10456

BIOPEP-UWM database of sensory peptides and amino acids: ID 8; 422

BRENDA: Ligand Arg-Gly

CAS: Registry No 2418-67-9

ChEMBL: ID CHEMBL382777

ChemIDplus: ID 002418679

ChemSpider: ID 4251526

DFBP: ID DFBPACEI1618

EPA DSSTox: ID DTXCID70101376

EROP-Moscow: ID E10392

J-GLOBAL ID: 200907074614271802

Metabolomics Workbench: ID 78683

Nikkaji: ID J80.480K

PubChem: CID 142765

SATPdb: ID satpdb12415

SureChEMBL: ID SCHEMBL2117673

Wikidata: ID Q83049384

ZINC: ID ZINC02545093