BIOPEP-UWM: Report

ID 10918
Name Neprilysin inhibitor
sequence
RP
Function:
Inhibitor of Neprilysin (EC 3.4.24.11) (MEROPS ID: M13.001)
 
Number of residues
2
Activity code
nep
Activity :
neprilysin inhibitor
Chemical mass 271.3153 Monoisotopic mass 271.1640
EC50 :
0.00 µM


Bibliographic data:
Authors
Moreno-Mariscal C., Carrera-Alvarado G., Mora L., Toldrá F.
Title
Neprilysin (NEP) and Angiotensin Converting Enzyme-I (ACE-I) inhibitory dipeptides from chicken carcass hydrolysates. LWT, 221, 117591, 2025
Year Source
2025 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: C1C[C@H](N(C1)C(=O)[C@H](CCCN=C(N)N)N)C(=O)O

InChI=1S/C11H21N5O3/c12-7(3-1-5-15-11(13)14)9(17)16-6-2-4-8(16)10(18)19/h7-8H,1-6,12H2,(H,18,19)(H4,13,14,15)/t7-,8-/m0/s1

InChIKey=LQJAALCCPOTJGB-YUMQZZPRSA-N


Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
Antinociceptive activity according to the ChEMBL database; the PubChem database
Affinity to neurotensin receptor according to the BIOPEP-UWM database (ID 10116); ChEMBL database; the PubChem database
Antiviral peptide according to the AVPdb database
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP database of bioactive peptides (ID 8518)
Inhibitor of angiotensin-converting enzyme according to the AHTPDB database, the BIOPEP database of bioactive peptides (ID 7582), the ChEMBL database; the EROP-Moscow database
Inhibitor of the neurolysin (EC 3.4.24.16) (MEROPS ID: M03.002) according to the BIOPEP database of bioactive peptides (ID 10171)

Bitter peptide according to the BIOPEP database of sensory peptides and amino acids (ID 11)
Salty taste enhancing peptide according to the BIOPEP database of sensory peptides and amino acids (ID 419)


Database reference:
ACToR: ID 2418-69-1

AHTPDB: ID 1120; 1390; 1470; 1502; 2793; 3054; 3056; 3083; 3179; 3221; 3533; 3583; 3789; 4021; 4442; 4495; 4676; 5423; 5452; 5641; 5676; 6114; 6568

AVPdb: ID AVP1054

BIOPEP database of bioactive peptides: ID 7582; 8518; 10116; 10171

BIOPEP database of sensory peptides and amino acids: ID 11; 419

BRENDA: Ligand Arg-Pro

CAS: Registry No 2418-69-1

ChEMBL: ID CHEMBL48223

ChemIDplus: ID 002418691

ChemSpider: ID 133095

DFBP: ID DFBPACEI1692, DFBPDPIV0020, DFBPMUFU0458

EPA CompTox: ID DTXSID70178886

EROP-Moscow: ID E10402

FooDB: ID FDB111774

HMDB: ID HMDB0028717

J-GLOBAL: ID 200907016181010197

MeSH: Terms Arg-Pro, arginylproline

Metabolomics Workbench: ID 78690

Nikkaji: ID J1.481.854E

PlantPepDB: ID PPepDB_180

PubChem: ID 151003

SATPdb: ID satpdb23927

Wikidata: ID Q83049386

ZINC: ID ZINC04899739