BIOPEP-UWM: Report

ID 10919
Name Neprilysin inhibitor
sequence
VE
Function:
Inhibitor of Neprilysin (EC 3.4.24.11) (MEROPS ID: M13.001)
 
Number of residues
2
Activity code
nep
Activity :
neprilysin inhibitor
Chemical mass 246.2596 Monoisotopic mass 246.1211
EC50 :
0.00 µM


Bibliographic data:
Authors
Moreno-Mariscal C., Carrera-Alvarado G., Mora L., Toldrá F.
Title
Neprilysin (NEP) and Angiotensin Converting Enzyme-I (ACE-I) inhibitory dipeptides from chicken carcass hydrolysates. LWT, 221, 117591, 2025
Year Source
2025 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)O

InChI=1S/C10H18N2O5/c1-5(2)8(11)9(15)12-6(10(16)17)3-4-7(13)14/h5-6,8H,3-4,11H2,1-2H3,(H,12,15)(H,13,14)(H,16,17)/t6-,8-/m0/s1

InChIKey=UPJONISHZRADBH-XPUUQOCRSA-N


Inhibitor of dipeptidyl peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8916)
Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database; the BIOPEP-UWM database of bioactive peptides (ID 7829); the BRENDA database; the EROP-Moscow database
Inhibitor of alpha-glucosidase (EC 3.2.1.20) according to the BIOPEP-UWM database of bioactive peptides (ID 9693)
Antioxidative peptide according to the DFBP database

Bitter taste according to BIOPEP-UWM database of sensory peptides and amino acids (ID 114);
Umami taste according to BIOPEP-UWM database of sensory peptides and amino acids (ID 262)
Sour taste according to BIOPEP-UWM database of sensory peptides and amino acids (ID 263)


Database reference:
AHTPDB: ID 3063; 3100; 3105; 3282; 3323; 3439; 4036; 5438; 6732

BioPepDB: ID biopep01347

BIOPEP-UWM database of bioactive peptides: ID 7829; 8916, 9693

BIOPEP-UWM database of sensory peptides and amino acids: ID 114; 262; 263

BRENDA: Ligand Val-Glu

CAS: Registry No 3062-07-5

ChEBI: ID 75011

ChemSpider: ID 5373203

DFBP: ID DFBPACEI0835; DFBPANOX0601; DFBPMUFU0491

EROP-Moscow: ID E01854

FooDB: ID FDB112128

HMDB: ID HMDB0029126

J-GLOBAL: ID 200907068917175610

Metabolights: ID MTBLC75011

Metabolomics Workbench: ID 79042

Nikkaji: ID J150.482G

NMRShiftDB: ID 60021765

PlantPepDB: ID PPepDB_199

PubChem: ID 7009623

SATPdb: ID satpdb23662

SureChEMBL: ID SCHEMBL156084

UniChem: ID 24085029

Wikidata: ID Q27145070

ZINC: ID ZINC000002384843