BIOPEP-UWM: Report

ID 11013
Name Hypotensive peptide
sequence
FRY

Function:
Peptide lowering blood pressure in rats
 
Number of residues
3
Activity code
hyp
Activity :
hypotensive
Chemical mass 484.5468 Monoisotopic mass 484.2427
EC50 :
0.00 µM



Bibliographic data:
Authors
Zhu R., Zhang H., Wu Y., Li H., Tang H., Xu X., Zhao K.
Title
Exploration and molecular mechanism of novel ACE inhibitory peptides from goat milk protein: A combined in silico and in vitro study. Int. Dairy J., 167, 106265, 2025
Year Source
2025 Journal



Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@H](CC1=CC=C(C=C1))C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)O

InChI=1S/C24H32N6O5/c25-18(13-15-5-2-1-3-6-15)21(32)29-19(7-4-12-28-24(26)27)22(33)30-20(23(34)35)14-16-8-10-17(31)11-9-16/h1-3,5-6,8-11,18-20,31H,4,7,12-14,25H2,(H,29,32)(H,30,33)(H,34,35)(H4,26,27,28)/t18-,19-,20-/m0/s1

InChIKey=IWRZUGHCHFZYQZ-UFYCRDLUSA-N



Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the BIOPEP-UWM database of bioactive peptides






Database reference:
BRENDA: Ligand Phe-Arg-Tyr

ChEBI: ID 161312

ChemSpider: ID 26363338

Metabolomics Workbench: ID 84294

PubChem: CID 129827425

UniChem: ID 161191016

Wikidata: ID Q106015593