BIOPEP-UWM: Report

ID 11112
Name Hypotensive peptide
sequence
VY
Function:
Lowering blood pressure
 
Number of residues
2
Activity code
hyp
Activity :
hypotensive
Chemical mass 280.3188 Monoisotopic mass 280.1418
EC50 :
0.00 µM


Bibliographic data:
Authors
Kawasaki T., Seki E., Osajima K., Yoshida M., Asada K., Matsui T., Osajima Y.
Title
Antihypertensive effect of valyl-tyrosine, a short chain peptide derived from sardine muscle hydrolyzate, on mild hypertensive subjects. J. Hum. Hypertens., 14, 519-523, 2000
Year Source
2000 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@]([H])(C(C)C)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)O

InChI=1S/C14H20N2O4/c1-8(2)12(15)13(18)16-11(14(19)20)7-9-3-5-10(17)6-4-9/h3-6,8,11-12,17H,7,15H2,1-2H3,(H,16,18)(H,19,20)/t11-,12-/m0/s1

InChIKey=VEYJKJORLPYVLO-RYUDHWBXSA-N


Found also in wheat milling by-products:

Nogata Y., Nagamine T., Yanaka M., Ohta H., 2009, Angiotensin I converting enzyme inhibitory peptides produced by autolysis reactions from wheat bran. J. Agric. Food Chem., 57, 6618-6622;

found in potato protein hydrolysates

Cheng Y., Chen J., Xiong Y. L., 2010, Chromatographic separation and tandem MS identification of active peptides in potato protein hydrolysate that inhibit autoxidation of soybean oil-in-water emulsions. J. Agric. Food Chem., 58, 8825-8832;

found in amaranth protein hydrolysate:

Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111


Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database; the BIOPEP database of bioactive peptides (ID 3492); the BRENDA database; the ChEMBL database; the EROP-Moscow database
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8929)
Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8224)
Inhibitor of Dipeptidyl peptidase-III (DPP-III) (EC 3.4.14.4) (MEROPS ID: M49.001) according to the BIOPEP-UWM database of bioactive peptides (ID 9509)
Inhibitor of Tripeptidyl peptidase 2 (TPP 2) (EC 3.4.14.10) (MEROPS ID: S08.090) according to the BIOPEP-UWM database of bioactive peptides (ID 10163)

Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 103)


Database reference:
AHTPDB: ID 1092; 1111; 1202; 1286; 1401; 1406; 1437; 1439; 1449; 1459; 1461; 1498; 1669; 1854; 1917; 1933; 2026; 2733; 2780; 2935; 2989; 3065; 3167; 3394; 3590; 3594; 3771; 3784; 4050; 4125; 4231; 4241; 4252; 4447; 4456; 4490; 4661; 4945; 4946; 5179; 5451; 5570; 5633; 6151; 6265; 6267; 6281; 6411; 6881

BindingDB: ID 50169147

BioPepDB: ID biopep01501

BIOPEP-UWM database of bioactive peptides: ID 3492; 8224; 8929, 9509, 10163

BIOPEP-UWM database of sensory peptides and amino acids: ID 103

BRENDA: Ligand Val-Tyr

CAS: Registry No 3061-91-4

ChEBI: ID 73703

ChEMBL: ID CHEMBL90069

ChemSpider: ID 5373134

DFBP: ID DFBPANHY0614, DFBPANHY0621, DFBPANHY0643, DFBPANHY0623, DFBPANHY0650, DFBPACEI0004, DFBPACEI0368, DFBPACEI0543, DFBPACEI1170, DFBPACEI1196, DFBPACEI1314, DFBPACEI1347, DFBPACEI1582, DFBPACEI1854, DFBPACEI1898, DFBPACEI1944, DFBPACEI1991, DFBPANOX0771, DFBPANOX0793

EPA CompTox: ID DTXSID50874591

EROP-Moscow: ID E09051

FooDB: ID FDB112140

HMDB: ID HMDB0029139

J-GLOBAL: ID 200907095117777910

MBPDB: Peptide VY

MeSH: Terms ANG-(3-4); Val-Tyr; valyl-tyrosine; valyltyrosine

Metabolights: ID MTBLC73703

Metabolomics Workbench: ID 79054

Nikkaji: ID J149.639E

NMRShiftDB: ID 60023310

PubChem: ID 7009554

SATPdb: ID satpdb21554

SDBS: ID SDBS-4359

SureChEMBL: ID SCHEMBL4273366

UniChem: ID 558534

Wikidata: ID Q27143866

ZINC: ID ZINC000002384776