BIOPEP-UWM: Report

ID 11140
Name ACE inhibitor
sequence
PPFLQPEV

Function:
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
 
Number of residues
9
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 926.0639 Monoisotopic mass 925.4893
IC50 :
1.57 µM



Bibliographic data:
Authors
Magouz O., Ibrahim M. A. A., Mehanna N., Gensberger-Reigl S., Dalabasmaz S., Pischetsrieder M.
Title
Identification of the heptapeptide PR7 and octapeptide SF8 with potent antioxidative and angiotensin converting enzyme inhibitory activity from the fermented dairy by-product “Buttermilk". Food Front., 6, 837–851, 2025
Year Source
2025 Journal



Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@]([H])(CO)C(=O)NCC(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)O

InChI=1S/C45H67N9O12/c1-25(2)23-31(50-40(60)32(24-27-11-6-5-7-12-27)51-42(62)34-15-9-21-53(34)43(63)29-13-8-20-47-29)39(59)49-30(16-18-35(46)55)44(64)54-22-10-14-33(54)41(61)48-28(17-19-36(56)57)38(58)52-37(26(3)4)45(65)66/h5-7,11-12,25-26,28-34,37,47H,8-10,13-24H2,1-4H3,(H2,46,55)(H,48,61)(H,49,59)(H,50,60)(H,51,62)(H,52,58)(H,56,57)(H,65,66)/t28-,29-,30-,31-,32-,33-,34-,37-/m0/s1

InChIKey=GAJFXZGNZSABJB-DCDHIVBYSA-N



Database reference: