BIOPEP-UWM: Report

ID 11152
Name ACE inhibitor
sequence
VLPVPQK

Function:
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
 
Number of residues
8
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 779.9643 Monoisotopic mass 779.4890
IC50 :
0.00 µM



Bibliographic data:
Authors
Magouz O., Ibrahim M. A. A., Mehanna N., Gensberger-Reigl S., Dalabasmaz S., Pischetsrieder M.
Title
Identification of the heptapeptide PR7 and octapeptide SF8 with potent antioxidative and angiotensin converting enzyme inhibitory activity from the fermented dairy by-product “Buttermilk". Food Front., 6, 837–851, 2025
Year Source
2025 Journal



Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCCCN)C(=O)O

InChI=1S/C37H65N9O9/c1-20(2)19-25(43-34(51)29(40)21(3)4)35(52)45-17-9-13-27(45)33(50)44-30(22(5)6)36(53)46-18-10-12-26(46)32(49)41-23(14-15-28(39)47)31(48)42-24(37(54)55)11-7-8-16-38/h20-27,29-30H,7-19,38,40H2,1-6H3,(H2,39,47)(H,41,49)(H,42,48)(H,43,51)(H,44,50)(H,54,55)/t23-,24-,25-,26-,27-,29-,30-/m0/s1

InChIKey=NKNBSECGZPVWGH-YYLRFZLMSA-N


Predicted ligand of Thrombin (EC 3.4.21.5) (MEROPS ID: S01.217) (PDB code: 2BVR) according to the BIOPEP-UWM Virtual database (ID 219)

Lipoxygenase inhibitor according to the BIOPEP-UWM database of bioactive peptides (ID 7877)
Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10243); the MBPDB database;
Antibacterial peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10242)
Peptide stimulating osteoblast differentiation according to the BIOPEP-UWM database of bioactive peptides (ID 10244); the MBPDB database
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 10246); the MBPDB database
Anti-apoptotic peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10245)
Peptide stimulating fibroblast migration and exhibiting antiaging effect according to the BIOPEP-UWM database of bioactive peptides (ID 10247); the MBPDB database








Database reference:
AHTPDB: ID 4343

BioPepDB: ID biopep01419

BIOPEP-UWM database of bioactive peptides: ID 7877; 10242; 10243; 10244; 10245; 10246; 10247

BIOPEP-UWM Virtual database: ID 219

DFBP: ID DFBPANOX0279; DFBPANTH0161; DFBPDPIV0189

EROP-Moscow: ID E14748

FeptideDB: ID 7877

J-Global: ID 200907043295090643

MBPDB: peptide VLPVPQK

Nikkaji: ID J1.075.676F

PubChem: CID 14389263

SATPdb: ID satpdb27718