BIOPEP-UWM: Report

ID 11205
Name PPARγ antagonist
sequence
WL
Function:
Antagonist of Peroxisome proliferator-activated receptor γ (PPARγ)
 
Number of residues
2
Activity code
ppar
Activity :
PPARγ antagonist
Chemical mass 317.3819 Monoisotopic mass 317.1734
EC50 :
0.00 µM


Bibliographic data:
Authors
Deng G., Liu Z., Ye F., Luo X., Zhu W., Shen X., Liu H., Jiang H.
Title
Tryptophan-containing dipeptide derivatives as potent PPARγ antagonists: Design, synthesis, biological evaluation, and molecular modeling. Eur. J. Med. Chem., 43, 2699-2716, 2008
Year Source
2008 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@H](CC1=C[NH]C2=CC=CC=C12)C(=O)N[C@@]([H])(CC(C)C)C(=O)O

InChI=1S/C17H23N3O3/c1-10(2)7-15(17(22)23)20-16(21)13(18)8-11-9-19-14-6-4-3-5-12(11)14/h3-6,9-10,13,15,19H,7-8,18H2,1-2H3,(H,20,21)(H,22,23)/t13-,15-/m0/s1

InChIKey=LYMVXFSTACVOLP-ZFWWWQNUSA-N


Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database; the BIOPEP-UWM database of bioactive peptides (ID 9107)
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8677)

Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids; the BitterDB database


Database reference:
AHTPDB: ID 1463; 1900; 2968; 4724; 5181; 6216; 6220; 6862

BindingDB: ID 50266681

BIOPEP-UWM database of bioactive peptides: ID 8677; 9107

BIOPEP-UWM database of sensory peptides and amino acids: ID 338

BRENDA: Ligand Trp-Leu

BitterDB: ID 830

ChEBI: ID 74871

ChEMBL: ID CHEMBL477627

ChemSpider: ID 5365198

eMolecules: ID 8294262

EROP-Moscow: ID E06385

FooDB: ID FDB098230

HMDB: ID HMDB0029087

J-GLOBAL: ID 200907089186452560

Metabolights: ID MTBLC74871

Metabolomics Workbench: ID 79006

Nikkaji: ID J236.159K

PLantPepDB: ID PPepDB_3839

PubChem: ID 6997509

Sabio-RK: ID 24732

SATPdb: ID satpdb20928

SureChEMBL: ID SCHEMBL7622341

Therapeutic Target Database (TTD): ID DNC009657

UniChem: ID 299509

Wikidata: ID Q27144982

ZINC: ID ZINC000001865984