BIOPEP-UWM: Report

ID 11208
Name PPARα agonist
sequence
WE
Function:
Agonist of Peroxisome proliferator-activated receptor α (PPARα)
 
Number of residues
2
Activity code
ppaa
Activity :
PPARα agonist
Chemical mass 333.3384 Monoisotopic mass 333.1320
EC50 :
0.00 µM


Bibliographic data:
Authors
Jia Y., Kim J.-H., Nama B., Kim J., Lee J. H., Hwang K.-Y., Lee S.-J.
Title
The dipeptide H-Trp-Glu-OH (WE) shows agonistic activity to peroxisome proliferator-activated protein-α and reduces hepatic lipid accumulation in lipid-loaded H4IIE cells. Bioorg. Med. Chem. Lett., 24, 2957–2962, 2014
Year Source
2014 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@H](CC1=C[NH]C2=CC=CC=C12)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)O

InChI=1S/C16H19N3O5/c17-11(7-9-8-18-12-4-2-1-3-10(9)12)15(22)19-13(16(23)24)5-6-14(20)21/h1-4,8,11,13,18H,5-7,17H2,(H,19,22)(H,20,21)(H,23,24)/t11-,13-/m0/s1

InChIKey=PWIQCLSQVQBOQV-AAEUAGOBSA-N


PPARα agonist according to the ChEMBL database
Hypolipidemic peptide according to the ChEMBL database
Hypocholesterolemic peptide according to the ChEMBL database
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides; the ChEMBL database; the EROP-Moscow database


Database reference:
BindingDB: ID 50240464

BIOPEP-UWM database of bioactive peptides: ID 8691

CAS: Registry No 36099-95-3

ChEBI: ID 74869

ChEMBL: ID CHEMBL39176

ChemSpider: ID5373243

eMolecules: 8830533

EPA CompTox: ID DTXSID00394512

EROP-Moscow: ID E26075

J-GLOBAL: ID 200907041358699780

Metabolomics Workbench: ID 79002

Nikkaji: ID J151.035E

PubChem: CID 7009663

SureChEMBL: ID SCHEMBL3547828

ZINC: ID ZINC000002384989