BIOPEP-UWM: Report

ID 11211
Name Thermolysin inhibitor
sequence
{H3PO4}LF
Function:
Inhibitor of thermolysin (EC 3.4.24.27) (MEROPS ID: M04.001)
 
Number of residues
3
Activity code
therm
Activity :
thermolysin inhibitor
Chemical mass 358.3258 Monoisotopic mass 358.1288
EC50 :
0.00 µM


Bibliographic data:
Authors
Kam C. M., Nishino N., Powers J. C.
Title
Inhibition of thermolysin and carboxypeptidase A by phosphoramidates. Biochemistry, 18, 3032-3038, 1979
Year Source
1979 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: OP(=O)(O)N[C@@]([H])(CC(C)C)C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)O

InChI=1S/C15H23N2O6P/c1-10(2)8-12(17-24(21,22)23)14(18)16-13(15(19)20)9-11-6-4-3-5-7-11/h3-7,10,12-13H,8-9H2,1-2H3,(H,16,18)(H,19,20)(H3,17,21,22,23)/t12-,13-/m0/s1

InChIKey=XHDKBRXIGMXIDI-STQMWFEESA-N


<H3PO4> - Phosphoric acid (ID 248 in the BIOPEP-UWM repository of amino acids and modifications)


Inhibitor of pseudolysin (EC 3.4.24.26; MEROPS ID: M04.005) according to the BIOPEP-UWM database of bioactive peptides; the BRENDA database


Database reference:
BRENDA: Ligand N-Phosphoryl-Leu-Phe-OH

CAS: Registry No 80826-98-8

ChemSpider: ID 117803

EPA CompTox: ID DTXCID501428492

J-Global: ID 200907076114040386

MeSH: terms phosphorylleucylphenylalanine; L-phenylalanine, N-(N-phosphono-L-leucyl)-; phospho-Leu-Phe; phosphoryl-Leu-Phe; phosphoryl-leucyl-phenylalanine

Nikkaji: ID J487.045J

PubChem: CID 133544

SureChEMBL: ID SCHEMBL29545788

UniChem: ID 42153719

Wikidata: ID Q82995488