BIOPEP-UWM: Report

ID 11218
Name Thermolysin inhibitor
sequence
{H3PO4}LW
Function:
Inhibitor of thermolysin (EC 3.4.24.27) (MEROPS ID: M04.001)
 
Number of residues
3
Activity code
therm
Activity :
thermolysin inhibitor
Chemical mass 397.3618 Monoisotopic mass 397.1397
IC50 :
0.00 µM


Bibliographic data:
Authors
Kam C. M., Nishino N., Powers J. C.
Title
Inhibition of thermolysin and carboxypeptidase A by phosphoramidates. Biochemistry, 18, 3032-3038, 1979
Year Source
1979 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: OP(=O)(O)N[C@@]([H])(CC(C)C)C(=O)N[C@@H](CC1=C[NH]C2=CC=CC=C12)C(=O)O

InChI=1S/C17H24N3O6P/c1-10(2)7-14(20-27(24,25)26)16(21)19-15(17(22)23)8-11-9-18-13-6-4-3-5-12(11)13/h3-6,9-10,14-15,18H,7-8H2,1-2H3,(H,19,21)(H,22,23)(H3,20,24,25,26)/t14-,15-/m0/s1

InChIKey=GKNMEOYLZHYYGW-GJZGRUSLSA-N


{H3PO4} - Phosphoric acid (ID 248 in the BIOPEP-UWM repository of amino acids and modifications)


Inhibitor of Endothelin-converting enzyme 1 (EC 3.4.24.71) (MEROPS ID: M13.002) according to the ChEMBL database


Database reference:
BindingDB: ID 50287436

BRENDA: Ligand N-Phosphoryl-Leu-Trp-OH

CAS: Registry No 56361-75-2

ChEMBL: ID CHEMBL291174

ChemSpider: ID 7976697

EPA CompTox: ID DTXSID10204916

FDA SRS: ID DM5WA46L8D

J-GLOBAL: ID 200907076832773073

Nikkaji: ID J487.044A

PubChem: CID 9800935

SureChEMBL: ID SCHEMBL14503216

UniChem: ID 587398

UNII: ID DM5WA46L8D

Wikidata: ID Q83078397

ZINC: ID ZINC000013515640