BIOPEP-UWM: Report

ID 11248
Name Antiapoptotic peptide
sequence
IRW

Function:
Antiapoptotic
 
Number of residues
3
Activity code
aapt
Activity :
anti-apoptotic
Chemical mass 473.5671 Monoisotopic mass 473.2743
EC50 :
0.00 µM



Bibliographic data:
Authors
Wang Z., Bao X., Rivas-Serna I. M., Lou Y., Mazurak V. C., Wu J.
Title
Transcriptomic and lipidomic analyses reveal a novel antiapoptotic mechanism of peptide IRW in the arteries of spontaneously hypertensive rats through the reduction of ceramide levels and arachidonic acid release. J. Agric. Food Chem., 73, 23404–23416, 2025
Year Source
2025 Journal



Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@H]([C@H](CC)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC1=C[N]([H])C2=CC=CC=C12)C(=O)O

InChI=1S/C23H35N7O4/c1-3-13(2)19(24)21(32)29-17(9-6-10-27-23(25)26)20(31)30-18(22(33)34)11-14-12-28-16-8-5-4-7-15(14)16/h4-5,7-8,12-13,17-19,28H,3,6,9-11,24H2,1-2H3,(H,29,32)(H,30,31)(H,33,34)(H4,25,26,27)/t13-,17-,18-,19-/m0/s1

InChIKey=ZXJFURYTPZMUNY-VKOGCVSHSA-N


Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database; the BIOPEP-UWM database of bioactive peptides (ID 9874); the DFBP database; the EROP-Moscow database
Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8213)
Hypotensive peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9875)
Anti-inflammatory peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9876)
Activator of Angiotensin 2-converting enzyme (EC 3.4.17.23) (MEROPS ID: M02.006) according to the BIOPEP-UWM database of bioactive peptides (ID 9877)
Peptide improving glucose tolerance in mice according to the BIOPEP-UWM database of bioactive peptides (ID 10786)



Database reference:
AHTPDB: ID 1938, 2041, 2211

BioPepDB: ID biopep00589

BIOPEP-UWM database of bioactive peptides: ID 8213; 9874; 9875; 9876; 9877; 10786

ChEBI: ID 158201

DFBP: ID DFBPACEI0140; DFBPANOX0782; DFBPMUFU0057

EROP-Moscow: ID E23666

FeptideDB: ID 8213

Metabolomics Workbench: ID 82693

PubChem: CID: 46912244

SATPdb: ID satpdb10670

UniChem: ID 32714337

Wikidata: ID Q106026714