BIOPEP-UWM: Report

ID 11263
Name Inhibitor of peptidylprolyl isomerase
sequence
<C2:0>APF<~!ph[4NO2]>
Function:
Inhibitor of peptidylprolyl isomerase (EC 5.2.1.8)
 
Number of residues
5
Activity code
ppi
Activity :
peptidylprolyl isomerase inhibitor
Chemical mass 495.5265 Monoisotopic mass 495.2111
IC50 :
770.00 µM


Bibliographic data:
Authors
Demange L., Moutiez M., Vaudry K., Dugave C.
Title
Interaction of human cyclophilin hCyp-18 with short peptides suggests the existence of two functionally independent subsites. FEBS Lett., 505, 191-195, 2001
Year Source
2001 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: CC(=O)N[C@@]([H])(C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)NC1=CC=C([N+](=O)[O-])C=C1

InChI=1S/C25H29N5O6/c1-16(26-17(2)31)25(34)29-14-6-9-22(29)24(33)28-21(15-18-7-4-3-5-8-18)23(32)27-19-10-12-20(13-11-19)30(35)36/h3-5,7-8,10-13,16,21-22H,6,9,14-15H2,1-2H3,(H,26,31)(H,27,32)(H,28,33)/t16-,21-,22-/m0/s1

InChIKey=WZYNCOIWGSLTHX-SSKFGXFMSA-N


<C2:0> - Acetic acid - N-terminal modification (ID 130 in the BIOPEP-UWM repository of amino acids and modifications)
<~!ph[4NO2]> - 4-Nitroaniline - C-terminal modification (ID 259 in the BIOPEP-UWM repository of amino acids and modifications)


Database reference:
BRENDA: Ligand acetyl-Ala-Pro-Phe-4-nitroanilide