BIOPEP-UWM: Report

ID 11264
Name Inhibitor of peptidylprolyl isomerase
sequence
<C2:0>APF<~!ph[4N(CH3)3]>
Function:
Inhibitor of peptidylprolyl isomerase (EC 5.2.1.8)
 
Number of residues
5
Activity code
ppi
Activity :
peptidylprolyl isomerase inhibitor
Chemical mass 508.6309 Monoisotopic mass 508.2915
IC50 :
7000.00 µM


Bibliographic data:
Authors
Demange L., Moutiez M., Vaudry K., Dugave C.
Title
Interaction of human cyclophilin hCyp-18 with short peptides suggests the existence of two functionally independent subsites. FEBS Lett., 505, 191-195, 2001
Year Source
2001 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: CC(=O)N[C@@]([H])(C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)NC1=CC=C([N+](C)(C)(C))C=C1

InChI=1S/C28H37N5O4/c1-19(29-20(2)34)28(37)32-17-9-12-25(32)27(36)31-24(18-21-10-7-6-8-11-21)26(35)30-22-13-15-23(16-14-22)33(3,4)5/h6-8,10-11,13-16,19,24-25H,9,12,17-18H2,1-5H3,(H2-,29,30,31,34,35,36)/p+1/t19-,24-,25-/m0/s1

InChIKey=FACOXEPPUHGTQT-LQGLAIQGSA-O


<C2:0> - Acetic acid - N-terminal modification (ID 130 in the BIOPEP-UWM repository of amino acids and modifications)
<~!ph[4N(CH3)3]> - 4-Amino-N,N,N-trimethylanilinium - C-terminal modification (ID 258 in the BIOPEP-UWM repository of amino acids and modifications)


Database reference:
BRENDA: Ligand acetyl-Ala-Pro-Phe-4-(trimethylammonium)anilide