BIOPEP-UWM: Report

ID 11266
Name Inhibitor of peptidylprolyl isomerase
sequence
<C3:0[3COOH]>AAPF<C2:0[2ph;6NH2]>
Function:
Inhibitor of peptidylprolyl isomerase (EC 5.2.1.8)
 
Number of residues
6
Activity code
ppi
Activity :
peptidylprolyl isomerase inhibitor
Chemical mass 637.6786 Monoisotopic mass 637.2738
IC50 :
4400.00 µM


Bibliographic data:
Authors
Demange L., Moutiez M., Vaudry K., Dugave C.
Title
Interaction of human cyclophilin hCyp-18 with short peptides suggests the existence of two functionally independent subsites. FEBS Lett., 505, 191-195, 2001
Year Source
2001 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: OC(=O)CCC(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)NC1=CC=C(C=C1)CC(=O)O

InChI=1S/C32H39N5O9/c1-19(33-26(38)14-15-27(39)40)29(43)34-20(2)32(46)37-16-6-9-25(37)31(45)36-24(17-21-7-4-3-5-8-21)30(44)35-23-12-10-22(11-13-23)18-28(41)42/h3-5,7-8,10-13,19-20,24-25H,6,9,14-18H2,1-2H3,(H,33,38)(H,34,43)(H,35,44)(H,36,45)(H,39,40)(H,41,42)/t19-,20-,24-,25-/m0/s1

InChIKey=HWYXFDQUUOJHDU-WNLYKICVSA-N


<C3:0[3COOH]> - Succinic acid - N-terminal modification (ID 257 in the BIOPEP-UWM repository of amino acids and modifications)
<C2:0[2ph;6NH2]> - 4-Aminophenylacetic acid (ID 260 in the BIOPEP-UWM repository of amino acids and modifications)


Database reference:
BRENDA: Ligand succinyl-Ala-Ala-Pro-Phe-4-carboxymethylanilide