BIOPEP-UWM: Report

ID 11267
Name Inhibitor of peptidylprolyl isomerase
sequence
<C3:0[3COOH]>AAP<~!ph[4NO2]>
Function:
Inhibitor of peptidylprolyl isomerase (EC 5.2.1.8)
 
Number of residues
6
Activity code
ppi
Activity :
peptidylprolyl isomerase inhibitor
Chemical mass 477.4667 Monoisotopic mass 477.1853
IC50 :
540.00 µM


Bibliographic data:
Authors
Demange L., Moutiez M., Vaudry K., Dugave C.
Title
Interaction of human cyclophilin hCyp-18 with short peptides suggests the existence of two functionally independent subsites. FEBS Lett., 505, 191-195, 2001
Year Source
2001 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: OC(=O)CCC(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N1[C@@]([H])(CCC1)C(=O)NC1=CC=C([N+](=O)[O-])C=C1

InChI=1S/C21H27N5O8/c1-12(22-17(27)9-10-18(28)29)19(30)23-13(2)21(32)25-11-3-4-16(25)20(31)24-14-5-7-15(8-6-14)26(33)34/h5-8,12-13,16H,3-4,9-11H2,1-2H3,(H,22,27)(H,23,30)(H,24,31)(H,28,29)/t12-,13-,16-/m0/s1

InChIKey=XTZBWJQWDZTXFI-XEZPLFJOSA-N


<C3:0[3COOH]> - Succinic acid - N-terminal modification (ID 257 in the BIOPEP-UWM repository of amino acids and modifications)
<~!ph[4NO2]> - 4-Nitroaniline - C-terminal modification (ID 259 in the BIOPEP-UWM repository of amino acids and modifications)


Database reference:
BRENDA: Ligand succinyl-Ala-Ala-Pro-Phe-4-nitroanilide