BIOPEP-UWM: Report

ID 11270
Name Inhibitor of peptidylprolyl isomerase
sequence
<C3:0[3COOH]>APF<C2:0[2ph;6NH2]>
Function:
Inhibitor of peptidylprolyl isomerase (EC 5.2.1.8)
 
Number of residues
5
Activity code
ppi
Activity :
peptidylprolyl isomerase inhibitor
Chemical mass 566.6009 Monoisotopic mass 566.2368
IC50 :
700.00 µM


Bibliographic data:
Authors
Demange L., Moutiez M., Vaudry K., Dugave C.
Title
Interaction of human cyclophilin hCyp-18 with short peptides suggests the existence of two functionally independent subsites. FEBS Lett., 505, 191-195, 2001
Year Source
2001 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: OC(=O)CCC(=O)N[C@@]([H])(C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)NC1=CC=C(C=C1)CC(=O)O

InChI=1S/C29H34N4O8/c1-18(30-24(34)13-14-25(35)36)29(41)33-15-5-8-23(33)28(40)32-22(16-19-6-3-2-4-7-19)27(39)31-21-11-9-20(10-12-21)17-26(37)38/h2-4,6-7,9-12,18,22-23H,5,8,13-17H2,1H3,(H,30,34)(H,31,39)(H,32,40)(H,35,36)(H,37,38)/t18-,22-,23-/m0/s1

InChIKey=SPYZKZMMZYDOMZ-TZYHBYERSA-N


<C3:0[3COOH]> - Succinic acid - N-terminal modification (ID 257 in the BIOPEP-UWM repository of amino acids and modifications)
<C2:0[2ph;6NH2]> - 4-Aminophenylacetic acid (ID 260 in the BIOPEP-UWM repository of amino acids and modifications)


Database reference:
BRENDA: Ligand succinyl-Ala-Pro-Phe-4-carboxmethylanilide