BIOPEP-UWM: Report

ID 11271
Name Inhibitor of peptidylprolyl isomerase
sequence
<C3:0[3COOH]>APF<~!ph[4NO2]>
Function:
Inhibitor of peptidylprolyl isomerase (EC 5.2.1.8)
 
Number of residues
5
Activity code
ppi
Activity :
peptidylprolyl isomerase inhibitor
Chemical mass 553.5625 Monoisotopic mass 553.2165
IC50 :
170.00 µM


Bibliographic data:
Authors
Demange L., Moutiez M., Vaudry K., Dugave C.
Title
Interaction of human cyclophilin hCyp-18 with short peptides suggests the existence of two functionally independent subsites. FEBS Lett., 505, 191-195, 2001
Year Source
2001 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: OC(=O)CCC(=O)N[C@@]([H])(C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)NC1=CC=C([N+](=O)[O-])C=C1

InChI=1S/C27H31N5O8/c1-17(28-23(33)13-14-24(34)35)27(38)31-15-5-8-22(31)26(37)30-21(16-18-6-3-2-4-7-18)25(36)29-19-9-11-20(12-10-19)32(39)40/h2-4,6-7,9-12,17,21-22H,5,8,13-16H2,1H3,(H,28,33)(H,29,36)(H,30,37)(H,34,35)/t17-,21-,22-/m0/s1

InChIKey=JDBBXEKOFQYNNF-HSQYWUDLSA-N


<C3:0[3COOH]> - Succinic acid - N-terminal modification (ID 257 in the BIOPEP-UWM repository of amino acids and modifications)
<~!ph[4NO2]> - 4-Nitroaniline - C-terminal modification (ID 259 in the BIOPEP-UWM repository of amino acids and modifications)


Database reference:
BRENDA: Ligand succinyl-Ala-Pro-Phe-4-nitroanilide