BIOPEP-UWM: Report

ID 11272
Name Inhibitor of peptidylprolyl isomerase
sequence
<C3:0[3COOH]>PF<~!ph[4NO2]>
Function:
Inhibitor of peptidylprolyl isomerase (EC 5.2.1.8)
 
Number of residues
4
Activity code
ppi
Activity :
peptidylprolyl isomerase inhibitor
Chemical mass 482.4848 Monoisotopic mass 482.1795
IC50 :
1090.00 µM


Bibliographic data:
Authors
Demange L., Moutiez M., Vaudry K., Dugave C.
Title
Interaction of human cyclophilin hCyp-18 with short peptides suggests the existence of two functionally independent subsites. FEBS Lett., 505, 191-195, 2001
Year Source
2001 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: OC(=O)CCC(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)NC1=CC=C([N+](=O)[O-])C=C1

InChI=1S/C24H26N4O7/c29-21(12-13-22(30)31)27-14-4-7-20(27)24(33)26-19(15-16-5-2-1-3-6-16)23(32)25-17-8-10-18(11-9-17)28(34)35/h1-3,5-6,8-11,19-20H,4,7,12-15H2,(H,25,32)(H,26,33)(H,30,31)/t19-,20-/m0/s1

InChIKey=LSIUBAIPOPGVQP-PMACEKPBSA-N


<C3:0[3COOH]> - Succinic acid - N-terminal modification (ID 257 in the BIOPEP-UWM repository of amino acids and modifications)
<~!ph[4NO2]> - 4-Nitroaniline - C-terminal modification (ID 259 in the BIOPEP-UWM repository of amino acids and modifications)


Database reference:
BRENDA: Ligand succinyl-Pro-Phe-4-nitroanilide