BIOPEP-UWM: Report

ID 11605
Name ACE inhibitor
sequence
KKYNVPQL
Function:
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
 
Number of residues
8
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 989.1658 Monoisotopic mass 988.5688
IC50 :
77.10 µM


Bibliographic data:
Authors
Gómez Ruiz J. Á., Ramos M., Recio I.
Title
Angiotensin converting enzyme-inhibitory activity of peptides isolated from Manchego cheese. Stability under simulated gastrointestinal digestion. Int. Dairy J., 14, 1075-1080, 2004
Year Source
2004 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(C(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)O

InChI=1S/C46H76N12O12/c1-25(2)22-34(46(69)70)56-41(64)31(17-18-36(50)60)53-44(67)35-12-9-21-58(35)45(68)38(26(3)4)57-43(66)33(24-37(51)61)55-42(65)32(23-27-13-15-28(59)16-14-27)54-40(63)30(11-6-8-20-48)52-39(62)29(49)10-5-7-19-47/h13-16,25-26,29-35,38,59H,5-12,17-24,47-49H2,1-4H3,(H2,50,60)(H2,51,61)(H,52,62)(H,53,67)(H,54,63)(H,55,65)(H,56,64)(H,57,66)(H,69,70)/t29-,30-,31-,32-,33-,34-,35-,38-/m0/s1

InChIKey=YUFPEDUFLYPJSC-MQXDESKPSA-N


Database reference:
AHTPDB: ID 3621, 4191, 4310, 5040, 5709

MBPDB: Peptide KKYNVPQL

Nikkaji: ID J2.108.785H

PubChem: CID 101358694

SATPdb: ID satpdb27901