BIOPEP-UWM: Report

ID 2570
Name VV-hemorphin-7
sequence
VVYPWTQRF
Function:
Ligand of mu, kappa and delta opioid receptors.
 
Number of residues
9
Activity code
op
Activity :
opioid
Chemical mass 1195.3651 Monoisotopic mass 1194.6167
EC50 :
0.00 µM


Bibliographic data:
Authors
Garreau I., Zhao Q., Pejoan C., Cupo A., Piot J. M.
Title
VV-hemorphin-7 and LVV-hemorphin-7 released during in vitro peptic hemoglobin hydrolysis are morphinomimetic peptides. Neuropeptides, 1995, 28, 243-250.
Year Source
1995 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES:
N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N2CCC[C@@H]2C(=O)N[C@@H](CC3=C[N](C4=C3C=CC=C4)[H])C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC5=CC=CC=C5)C(=O)O

InChI=1S/C59H82N14O13/c1-31(2)47(61)54(81)71-48(32(3)4)55(82)69-43(27-35-19-21-37(75)22-20-35)57(84)73-26-12-18-45(73)53(80)68-42(29-36-30-65-39-16-10-9-15-38(36)39)52(79)72-49(33(5)74)56(83)67-41(23-24-46(60)76)51(78)66-40(17-11-25-64-59(62)63)50(77)70-44(58(85)86)28-34-13-7-6-8-14-34/h6-10,13-16,19-22,30-33,40-45,47-49,65,74-75H,11-12,17-18,23-29,61H2,1-5H3,(H2,60,76)(H,66,78)(H,67,83)(H,68,80)(H,69,82)(H,70,77)(H,71,81)(H,72,79)(H,85,86)(H4,62,63,64)/t33-,40+,41+,42+,43+,44+,45+,47+,48+,49+/m1/s1

InChIKey: FFBBHLKDMHCFTH-AKYHLAPZSA-N

Another reference concerning opioid activity:
Szikra J., Benyhe S., Orosz G., Darula Z., Piot J. M., Fruitier I., Monory K., Hanoune J., Borsodi A., 2001, Radioligand binding properties of VV-hemorphin 7, an atypical opioid peptide. Biochem. Biophys. Res. Commun., 281, 670-677


Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database; BIOPEP-UWM database of bioactive peptides (ID 9001)

Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 404)


Database reference:
AHTPDB: ID 1047, 2342, 2739, 2826, 2880, 2923, 3713, 4216, 4474, 4614

BIOPEP-UWM database of bioactive peptides: ID 9001

BIOPEP-UWM database of sensory peptides and amino acids: ID 404

ChemIDplus: ID 075808672

ChemSpider: ID 112435

EROP-Moscow: ID E00289

FeptideDB: ID 2570

J-GLOBAL: ID 200907021779059992

Nikkaji: ID J654.605F

PepBank: peptide VVYPWTQRF

PubChem: CID 126533

SATPdb: ID satpdb17026