BIOPEP-UWM: Report

ID 2595
Name tachylepsin III from homocytes of horse shoe crab
sequence
KWCFRVCYRGICYRRCR~
Function:
Antimicrobial
 
Number of residues
17
Activity code
ab
Activity :
antibacterial
Chemical mass 2267.7713 Monoisotopic mass 2266.1090
EC50 :
0.00 µM


Bibliographic data:
Authors
Nakamura T., Furunaka H., Miyata T., Tokunaga F., Muta T., Iwanaga S.
Title
Tachyplesin, a class of antimocrobial peptide from the hemocytes of the horseshoe crab (Tachypleus tridentatus). Isolation and chemical structure. J. Biol. Chem., 263, 16709-16713, 1988
Year Source
1988 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@](C(N[C@](C(N[C@](C(N[C@](C(N[C@](C(N[C@](C(N[C@](C(N[C@](C(N[C@](C(NCC(N[C@](C(N[C@](C(N[C@](C(N[C@](C(N[C@](C(N[C@](C(N[C@](C(N)=O)(CCCNC(N)=N)[H])=O)(CS)[H])=O)(CCCNC(N)=N)[H])=O)(CCCNC(N)=N)[H])=O)(Cc1ccc(O)cc1)[H])=O)(CS)[H])=O)(C(C)CC)[H])=O)=O)(CCCNC(N)=N)[H])=O)(Cc1ccc(O)cc1)[H])=O)(CS)[H])=O)(C(C)C)[H])=O)(CCCNC(N)=N)[H])=O)(Cc1ccccc1)[H])=O)(CS)[H])=O)(Cc1c2ccccc2[nH]c1)[H])=O)(CCCCN)[H]

InChI=1S/C99H155N35O19S4/c1-5-53(4)78(94(153)132-75(51-157)92(151)128-70(44-56-30-34-59(136)35-31-56)87(146)123-65(25-15-39-115-97(107)108)82(141)122-66(26-16-40-116-98(109)110)83(142)129-72(48-154)89(148)120-63(79(102)138)23-13-37-113-95(103)104)133-76(137)47-119-81(140)64(24-14-38-114-96(105)106)121-85(144)69(43-55-28-32-58(135)33-29-55)127-91(150)74(50-156)131-93(152)77(52(2)3)134-84(143)67(27-17-41-117-99(111)112)124-86(145)68(42-54-18-7-6-8-19-54)126-90(149)73(49-155)130-88(147)71(125-80(139)61(101)21-11-12-36-100)45-57-46-118-62-22-10-9-20-60(57)62/h6-10,18-20,22,28-35,46,52-53,61,63-75,77-78,118,135-136,154-157H,5,11-17,21,23-27,36-45,47-51,100-101H2,1-4H3,(H2,102,138)(H,119,140)(H,120,148)(H,121,144)(H,122,141)(H,123,146)(H,124,145)(H,125,139)(H,126,149)(H,127,150)(H,128,151)(H,129,142)(H,130,147)(H,131,152)(H,132,153)(H,133,137)(H,134,143)(H4,103,104,113)(H4,105,106,114)(H4,107,108,115)(H4,109,110,116)(H4,111,112,117)/t53?,61-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,77-,78-/m0/s1

InChIKey: NJWHFJXPCVKWIE-LYHKCUKESA-N


The active form of this peptide is C-terminal amide. This peptide is active against G(+) and G(-) bacteria.


Hemolytic peptide according to the Hemolytik database


Database reference:
APD: ID AP00214

EROP-Moscow: ID E03814

Hemolytik: ID 2435

PepBank: Peptide KWCFRVCYRGICYRRCR

SATPdb: ID satpdb16987