BIOPEP-UWM: Report

ID 2601
Name Tachykinin family from white shrimp Penaeus vannamei
sequence
APSGFLGMRG
Function:
Precursor of neuropeptide
 
Number of residues
10
Activity code
ne
Activity :
neuropeptide
Chemical mass 992.1512 Monoisotopic mass 991.4894
EC50 :
0.00 µM


Bibliographic data:
Authors
Nieto J., Veelaert D., Derua R., Waelkens E., Cerstiaens A., Coast G., Devreese B., Van Beeumen J., Calderon J., De Loof A., Schoofs L.
Title
Identification of one tachykinin and two kinin related peptides in the brain of the white shrimp, Penaeus vannamei. Biochem. Biophys. Res. Comm., 248, 406-411 (1998).
Year Source
1998 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: [H][C@@](C)(N)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CO)C(=O)NCC(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)NCC(O)=O

InChI=1S/C43H69N13O12S/c1-24(2)18-29(37(63)48-20-33(58)51-28(14-17-69-4)39(65)53-27(12-8-15-47-43(45)46)36(62)50-22-35(60)61)54-40(66)30(19-26-10-6-5-7-11-26)52-34(59)21-49-38(64)31(23-57)55-41(67)32-13-9-16-56(32)42(68)25(3)44/h5-7,10-11,24-25,27-32,57H,8-9,12-23,44H2,1-4H3,(H,48,63)(H,49,64)(H,50,62)(H,51,58)(H,52,59)(H,53,65)(H,54,66)(H,55,67)(H,60,61)(H4,45,46,47)/t25-,27-,28-,29-,30-,31-,32-/m0/s1

InChIKey: UPAJFDNABZANJN-CXZRMZRFSA-N

The active form is C-terminal amide group instead of C-terminal glycine residue.

Peptide is the precursor of neuropeptide (ID 2604 in BIOPEP-UWM database of bioactive peptides).

Reviews concerning C-terminal amidation of peptides:

Bradbury A. F., Smyth D. G., 1991, Peptide amidation. Trends Biochem. Sci., 16, 112-115

Merkler D. J., 1994, C-terminal amidated peptides: production by the in vitro enzymatic amidation of glycine-extended peptides and the importance of the amide to bioactivity. Enzyme Microb. Technol., 16, 450-456


Database reference:
EROP-Moscow: ID E10658

PepBank: Peptide APSGFLGMR