BIOPEP-UWM: Report

ID 2610
Name PEP inhibitor
sequence
IYPFPGPIH

Function:
Inhibitor of prolyl oligopeptidase (EC 3.4.21.26) (MEROPS ID: S09.001)
 
Number of residues
9
Activity code
am
Activity :
antiamnestic
Chemical mass 1040.2109 Monoisotopic mass 1039.5474
EC50 :
50.00 µM



Bibliographic data:
Authors
Asano M., Nio N., Ariyoshi Y.
Title
Inhibition of prolyl endopeptidase by synthetic beta-casein peptides and their derivatives with a C-terminal prolinol or prolinal. Biosci. Biotech. Biochem., 56, 976-977 (1992)
Year Source
1992 Journal



Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: [H][C@@](Cc1cnc[nH]1)(NC(=O)[C@@]([H])(NC(=O)[C@]1([H])CCCN1C(=O)CNC(=O)[C@]1([H])CCCN1C(=O)[C@]([H])(Cc1ccccc1)NC(=O)[C@]1([H])CCCN1C(=O)[C@]([H])(Cc1ccc(O)cc1)NC(=O)[C@@]([H])(N)[C@@H](C)CC)[C@@H](C)CC)C(O)=O

InChI=1S/C53H73N11O11/c1-5-31(3)44(54)49(70)59-38(26-34-18-20-36(65)21-19-34)52(73)64-24-12-17-42(64)47(68)58-37(25-33-13-8-7-9-14-33)51(72)63-23-11-15-40(63)46(67)56-29-43(66)62-22-10-16-41(62)48(69)61-45(32(4)6-2)50(71)60-39(53(74)75)27-35-28-55-30-57-35/h7-9,13-14,18-21,28,30-32,37-42,44-45,65H,5-6,10-12,15-17,22-27,29,54H2,1-4H3,(H,55,57)(H,56,67)(H,58,68)(H,59,70)(H,60,71)(H,61,69)(H,74,75)/t31-,32-,37-,38-,39-,40-,41-,42-,44-,45-/m0/s1

InChIKey: OYZAWCLFLKBAFA-OGRHEWHMSA-N



Database reference: