BIOPEP-UWM: Report

ID 2612
Name PEP inhibitor
sequence
VYPFPGPIA

Function:
Inhibitor of prolyl oligopeptidase (EC 3.4.21.26) (MEROPS ID: S09.001)
 
Number of residues
9
Activity code
am
Activity :
antiamnestic
Chemical mass 960.1231 Monoisotopic mass 959.5100
EC50 :
45.00 µM



Bibliographic data:
Authors
Asano M., Nio N., Ariyoshi Y.
Title
Inhibition of prolyl endopeptidase by synthetic beta-casein peptides and their derivatives with a C-terminal prolinol or prolinal. Biosci. Biotech. Biochem., 56, 976-977 (1992)
Year Source
1992 Journal



Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: [H][C@@](C)(NC(=O)[C@@]([H])(NC(=O)[C@]1([H])CCCN1C(=O)CNC(=O)[C@]1([H])CCCN1C(=O)[C@]([H])(Cc1ccccc1)NC(=O)[C@]1([H])CCCN1C(=O)[C@]([H])(Cc1ccc(O)cc1)NC(=O)[C@@]([H])(N)C(C)C)[C@@H](C)CC)C(O)=O

InChI=1S/C49H69N9O11/c1-6-29(4)41(46(65)52-30(5)49(68)69)55-44(63)37-16-10-22-56(37)39(60)27-51-42(61)36-15-11-23-57(36)47(66)34(25-31-13-8-7-9-14-31)53-43(62)38-17-12-24-58(38)48(67)35(54-45(64)40(50)28(2)3)26-32-18-20-33(59)21-19-32/h7-9,13-14,18-21,28-30,34-38,40-41,59H,6,10-12,15-17,22-27,50H2,1-5H3,(H,51,61)(H,52,65)(H,53,62)(H,54,64)(H,55,63)(H,68,69)/t29-,30-,34-,35-,36-,37-,38-,40-,41-/m0/s1

InChIKey: XPMDFESOWXWBST-MGGQXHRESA-N



Database reference: