BIOPEP-UWM: Report

ID 2615
Name PEP inhibitor
sequence
VYPFPGPI
Function:
Inhibitor of prolyl oligopeptidase (EC 3.4.21.26) (MEROPS ID: S09.001)
 
Number of residues
8
Activity code
am
Activity :
antiamnestic
Chemical mass 889.0454 Monoisotopic mass 888.4730
EC50 :
110.00 µM


Bibliographic data:
Authors
Asano M., Nio N., Ariyoshi Y.
Title
Inhibition of prolyl endopeptidase by synthetic beta-casein peptides and their derivatives with a C-terminal prolinol or prolinal. Biosci. Biotech. Biochem., 56, 976-977 (1992)
Year Source
1992 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: [H][C@](N)(C(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N1CCC[C@@]1([H])C(=O)NCC(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])([C@@H](C)CC)C(O)=O

InChI=1S/C46H64N8O10/c1-5-28(4)39(46(63)64)51-42(59)35-15-9-21-52(35)37(56)26-48-40(57)34-14-10-22-53(34)44(61)32(24-29-12-7-6-8-13-29)49-41(58)36-16-11-23-54(36)45(62)33(50-43(60)38(47)27(2)3)25-30-17-19-31(55)20-18-30/h6-8,12-13,17-20,27-28,32-36,38-39,55H,5,9-11,14-16,21-26,47H2,1-4H3,(H,48,57)(H,49,58)(H,50,60)(H,51,59)(H,63,64)/t28-,32-,33-,34-,35-,36-,38-,39-/m0/s1

InChIKey: MJFASUNIWIJBFR-YIUNQBEOSA-N


Inhibitor of angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database; the BIOPEP-UWM database of bioactive peptides


Database reference:
AHTPDB: ID 3407, 6502

BIOPEP-UWM database of bioactive peptides: ID 7492

EROP-Moscow: ID E14659

MBPDB: Peptide VYPFPGPI

PepBank: Peptide VYPFPGPI

SATPdb: ID satpdb10777