BIOPEP-UWM: Report

ID 2632
Name ACE inhibitor
sequence
QPQPLIYP
Function:
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
 
Number of residues
8
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 955.1050 Monoisotopic mass 954.5158
EC50 :
4.00 µM


Bibliographic data:
Authors
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Title
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
Year Source
1989 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: [H][C@](N)(CCC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(O)=O

InChI=1S/C46H70N10O12/c1-5-26(4)38(42(63)52-32(24-27-12-14-28(57)15-13-27)45(66)56-22-8-11-35(56)46(67)68)53-39(60)31(23-25(2)3)51-41(62)34-10-7-21-55(34)44(65)30(17-19-37(49)59)50-40(61)33-9-6-20-54(33)43(64)29(47)16-18-36(48)58/h12-15,25-26,29-35,38,57H,5-11,16-24,47H2,1-4H3,(H2,48,58)(H2,49,59)(H,50,61)(H,51,62)(H,52,63)(H,53,60)(H,67,68)/t26-,29-,30-,31-,32-,33-,34-,35-,38-/m0/s1

InChIKey: WTJUWXYRNVDNPM-NGLZDHJISA-N


Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/); ID: M02-001


Database reference:
AHTPDB: ID 5971, 6301, 6796

EROP-Moscow: ID E14587

MBPDB: Peptide QPQPLIYP

SATPdb: ID satpdb11379