BIOPEP-UWM: Report

ID 2641
Name ACE inhibitor
sequence
DKIYPSFQPQPLIYP
Function:
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
 
Number of residues
15
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 1806.0596 Monoisotopic mass 1804.9369
EC50 :
107.00 µM


Bibliographic data:
Authors
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Title
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
Year Source
1989 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: [H][C@](N)(CC(O)=O)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(O)=O

InChI=1S/C88H128N18O23/c1-7-49(5)72(101-75(115)57(20-12-13-37-89)93-74(114)56(90)46-71(112)113)82(122)98-62(44-52-25-29-54(108)30-26-52)86(126)105-40-16-23-67(105)81(121)100-64(47-107)78(118)96-61(43-51-18-10-9-11-19-51)76(116)94-58(33-35-69(91)110)84(124)103-38-14-21-65(103)79(119)95-59(34-36-70(92)111)85(125)104-39-15-22-66(104)80(120)97-60(42-48(3)4)77(117)102-73(50(6)8-2)83(123)99-63(45-53-27-31-55(109)32-28-53)87(127)106-41-17-24-68(106)88(128)129/h9-11,18-19,25-32,48-50,56-68,72-73,107-109H,7-8,12-17,20-24,33-47,89-90H2,1-6H3,(H2,91,110)(H2,92,111)(H,93,114)(H,94,116)(H,95,119)(H,96,118)(H,97,120)(H,98,122)(H,99,123)(H,100,121)(H,101,115)(H,102,117)(H,112,113)(H,128,129)/t49-,50-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,72-,73-/m0/s1

InChIKey: MWRSGZAWWSFCCF-INNFGACBSA-N


Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/); ID: M02-001


Database reference:
AHTPDB: ID 5978, 6308, 6803

EROP-Moscow: ID E14594

MBPDB: Peptide DKIYPSFQPQPLIYP

SATPdb: ID satpdb16363