BIOPEP-UWM: Report

ID 2667
Name ACE inhibitor
sequence
LHLPLP
Function:
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
 
Number of residues
6
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 688.8556 Monoisotopic mass 688.4259
EC50 :
2.90 µM


Bibliographic data:
Authors
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Title
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
Year Source
1989 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: [H][C@](N)(CC(C)C)C(=O)N[C@@]([H])(Cc1cnc[nH]1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CC(C)C)C(=O)N1CCC[C@@]1([H])C(O)=O

InChI=1S/C34H56N8O7/c1-19(2)13-23(35)29(43)38-24(16-22-17-36-18-37-22)30(44)39-25(14-20(3)4)32(46)41-11-7-9-27(41)31(45)40-26(15-21(5)6)33(47)42-12-8-10-28(42)34(48)49/h17-21,23-28H,7-16,35H2,1-6H3,(H,36,37)(H,38,43)(H,39,44)(H,40,45)(H,48,49)/t23-,24-,25-,26-,27-,28-/m0/s1

InChIKey: QLFCYFCBEUPIBA-QUQVWLGBSA-N


Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/); ID: M02-001

Another value of peptide IC50(EC50)=5,5uM.

Hernández-Ledesma B., Quirós A., Amigo L., Recio I., 2007, Identification of bioactive peptides after digestion of human milk and infant formula with pepsin and pancreatin. Int. Dairy J., 17, 42-49


Database reference:
AHTPDB: ID 1712, 1748, 1760, 1939, 2616, 3457, 3644, 3668, 4180, 4338, 5023, 5365, 5818, 5824, 6002, 6330, 6788, 6827

BindingDB: ID 50049852

ChEMBL: ID CHEMBL3322134

ChemSpider: ID 8115463

EROP-Moscow: ID E09375

J-GLOBAL: ID 200907056906210580

MBPDB: Peptide LHLPLP

Nikkaji: J2.550.474G

PubChem: CID 9939842

SATPdb: ID satpdb20721

ZINC: ID ZINC000195981346