BIOPEP-UWM: Report
| ID | 2674 |
| Name | substance P |
| sequence |
| Function: | |||
| Inhibits the proliferation of the small cell lung cancer (SCLC). | |||
| Number of residues | 11 |
Activity code | ac |
| Activity : | anticancer |
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| Chemical mass | 1347.6272 | Monoisotopic mass | 1346.7260 | |
| EC50 : | 0.00 µM |
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| Bibliographic data: | |
| Authors | |
| Nyeki O., Rill A., Schon I., Orosz A., Schrett J., Bartha L., Nagy J. | |
| Title | |
| Synthesis of peptide and pseudopeptide amides inhibiting the proliferation of small cell and epithelial types of lung carcinoma cells. J. Pept. Sci., 4, 486-495 (1998). | |
| Year | Source |
| 1998 | Journal |
| Additional information: |
| BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CCCNC(N)=N)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCCCN)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)NCC(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCSC)C(N)=O InChI=1S/C63H98N18O13S/c1-37(2)33-45(57(89)74-41(53(68)85)27-32-95-3)73-52(84)36-72-54(86)46(34-38-15-6-4-7-16-38)78-58(90)47(35-39-17-8-5-9-18-39)79-56(88)42(23-25-50(66)82)75-55(87)43(24-26-51(67)83)76-59(91)49-22-14-31-81(49)62(94)44(20-10-11-28-64)77-60(92)48-21-13-30-80(48)61(93)40(65)19-12-29-71-63(69)70/h4-9,15-18,37,40-49H,10-14,19-36,64-65H2,1-3H3,(H2,66,82)(H2,67,83)(H2,68,85)(H,72,86)(H,73,84)(H,74,89)(H,75,87)(H,76,91)(H,77,92)(H,78,90)(H,79,88)(H4,69,70,71)/t40-,41-,42-,43-,44-,45-,46-,47-,48-,49-/m0/s1 InChIKey: ADNPLDHMAVUMIW-CUZNLEPHSA-N The active form of this peptide is C-terminal amide. Inhibitor of Neprilysin 2 (EC 3.4.24.B14) (MEROPS ID: M13.008) according to the BRENDA database Neuropeptide according to the ChEMBL database; the Neuropedia database,the NeuroPep database, the PubChem database Peptide inducing smooth muscle contraction according to the ChEMBL database Antimicrobial peptide according to the APD database; the CAMP database |
| Database reference: |