BIOPEP-UWM: Report

ID 2687
Name
sequence
GGCADGPTLREWISFCGG
Function:
stimulating blood platelet production
 
Number of residues
18
Activity code
sti
Activity :
stimulating
Chemical mass 1826.0156 Monoisotopic mass 1824.7897
EC50 :
0.00 µM


Bibliographic data:
Authors
Cwirla S. E., Balasubramanian P., Duffin D. J., Wagstrom C. R., Gates C. M., Singer S. C., Davis A. M., Tansik R. L., Mattheakis L. C., Boytos C. M.,
Title
Peptide agonist of the thrombopoietin receptor as potent as the natural cytokine. Science, 276, 1696-1699, 1997
Year Source
1997 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: [H][C@](C)(O)[C@]([H])(NC(=O)[C@]1([H])CCCN1C(=O)CNC(=O)[C@]([H])(CC(O)=O)NC(=O)[C@]([H])(C)NC(=O)[C@]([H])(CS)NC(=O)CNC(=O)CN)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@]([H])(C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CS)C(=O)NCC(=O)NCC(O)=O)[C@@]([H])(C)CC


InChI=1S/C78H116N22O25S2/c1-7-39(4)63(76(124)96-52(35-101)73(121)93-49(26-42-15-9-8-10-16-42)71(119)97-53(36-126)67(115)86-31-57(104)85-34-62(111)112)98-72(120)50(27-43-30-83-45-18-12-11-17-44(43)45)94-69(117)47(21-22-60(107)108)91-68(116)46(19-13-23-82-78(80)81)90-70(118)48(25-38(2)3)95-77(125)64(41(6)102)99-75(123)55-20-14-24-100(55)59(106)33-87-66(114)51(28-61(109)110)92-65(113)40(5)88-74(122)54(37-127)89-58(105)32-84-56(103)29-79/h8-12,15-18,30,38-41,46-55,63-64,83,101-102,126-127H,7,13-14,19-29,31-37,79H2,1-6H3,(H,84,103)(H,85,104)(H,86,115)(H,87,114)(H,88,122)(H,89,105)(H,90,118)(H,91,116)(H,92,113)(H,93,121)(H,94,117)(H,95,125)(H,96,124)(H,97,119)(H,98,120)(H,99,123)(H,107,108)(H,109,110)(H,111,112)(H4,80,81,82)/t39-,40-,41+,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,63-,64-/m0/s1

InChIKey=LSQWPRNQLSHHLE-XWLOCTIGSA-N


Database reference: