BIOPEP-UWM: Report

ID 2689
Name Erythropoietin mimetic
sequence
GGLYLCRFGPVTWDCGYKGG
Function:
stimulating blood platelet creation
 
Number of residues
20
Activity code
sti
Activity :
stimulating
Chemical mass 2149.4466 Monoisotopic mass 2147.9889
EC50 :
0.00 µM


Bibliographic data:
Authors
Wrighton N. C., Farrell F. X., Chang R., Kashyap A. K., Barbone F. P., Mulcahy L. S., Johnson D. L., Barrett R. W., Jolliffe L. K., Dower W. J.
Title
Small peptides as potent mimetics of the protein hormone erythropoietin. Science, 273, 458-463, 1996
Year Source
1996 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: [H][C@@](CS)(NC(=O)[C@]([H])(CC(O)=O)NC(=O)[C@]([H])(Cc1c[nH]c2ccccc12)NC(=O)[C@@]([H])(NC(=O)[C@@]([H])(NC(=O)[C@]1([H])CCCN1C(=O)CNC(=O)[C@]([H])(Cc1ccccc1)NC(=O)[C@]([H])(CCCNC(N)=N)NC(=O)[C@]([H])(CS)NC(=O)[C@]([H])(CC(C)C)NC(=O)[C@]([H])(Cc1ccc(O)cc1)NC(=O)[C@]([H])(CC(C)C)NC(=O)CNC(=O)CN)C(C)C)[C@@H](C)O)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CCCCN)C(=O)NCC(=O)NCC(O)=O

InChI=1S/C98H141N25O26S2/c1-51(2)35-65(110-77(129)45-105-75(127)42-100)88(140)116-69(39-57-26-30-60(126)31-27-57)91(143)114-66(36-52(3)4)89(141)120-73(50-151)94(146)113-64(22-15-33-103-98(101)102)87(139)115-67(37-55-17-9-8-10-18-55)85(137)109-47-79(131)123-34-16-23-74(123)95(147)121-82(53(5)6)96(148)122-83(54(7)124)97(149)118-70(40-58-43-104-62-20-12-11-19-61(58)62)92(144)117-71(41-80(132)133)93(145)119-72(49-150)86(138)108-46-78(130)111-68(38-56-24-28-59(125)29-25-56)90(142)112-63(21-13-14-32-99)84(136)107-44-76(128)106-48-81(134)135/h8-12,17-20,24-31,43,51-54,63-74,82-83,104,124-126,150-151H,13-16,21-23,32-42,44-50,99-100H2,1-7H3,(H,105,127)(H,106,128)(H,107,136)(H,108,138)(H,109,137)(H,110,129)(H,111,130)(H,112,142)(H,113,146)(H,114,143)(H,115,139)(H,116,140)(H,117,144)(H,118,149)(H,119,145)(H,120,141)(H,121,147)(H,122,148)(H,132,133)(H,134,135)(H4,101,102,103)/t54-,63+,64+,65+,66+,67+,68+,69+,70+,71+,72+,73+,74+,82+,83+/m1/s1

InChIKey: ZTJHTXAIJJUGEK-XBPNOPTBSA-N


Database reference: