BIOPEP-UWM: Report

ID 2730
Name renin inhibitor
sequence
PHPFHFFVYK
Function:
Inhibitor of Renin (EC 3.4.23.15) (MEROPS ID A01.007)
 
Number of residues
10
Activity code
ren
Activity :
renin inhibitor
Chemical mass 1318.5189 Monoisotopic mass 1317.6639
EC50 :
0.00 µM


Bibliographic data:
Authors
Burton J., Cody R. J., Herd J. A., Haber E.
Title
Specific inhibition of renin by an angiotensinogen analog: studies in sodium depletion and renin-dependent hypertension. Proc. Natl Acad. Sci. USA, 77, 5476-5479, 1980
Year Source
1980 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: [H][C@@](CCCCN)(NC(=O)[C@]([H])(Cc1ccc(O)cc1)NC(=O)[C@@]([H])(NC(=O)[C@]([H])(Cc1ccccc1)NC(=O)[C@]([H])(Cc1ccccc1)NC(=O)[C@]([H])(Cc1cnc[nH]1)NC(=O)[C@]([H])(Cc1ccccc1)NC(=O)[C@]1([H])CCCN1C(=O)[C@]([H])(Cc1cnc[nH]1)NC(=O)[C@]1([H])CCCN1)C(C)C)C(O)=O

InChI=1S/C69H87N15O12/c1-42(2)59(67(93)81-54(35-46-25-27-49(85)28-26-46)61(87)76-51(69(95)96)22-12-13-29-70)83-65(91)55(34-45-20-10-5-11-21-45)78-62(88)52(32-43-16-6-3-7-17-43)77-64(90)56(36-47-38-71-40-74-47)79-63(89)53(33-44-18-8-4-9-19-44)80-66(92)58-24-15-31-84(58)68(94)57(37-48-39-72-41-75-48)82-60(86)50-23-14-30-73-50/h3-11,16-21,25-28,38-42,50-59,73,85H,12-15,22-24,29-37,70H2,1-2H3,(H,71,74)(H,72,75)(H,76,87)(H,77,90)(H,78,88)(H,79,89)(H,80,92)(H,81,93)(H,82,86)(H,83,91)(H,95,96)/t50-,51-,52-,53-,54-,55-,56-,57-,58-,59-/m0/s1

InChIKey=AIRMFERKNRDUKD-PVGXKDMPSA-N


Information concerning Renin is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/); ID: A01.007

Review concerning peptide:
Ondetti M. A., Cushman D. W., 1982, Enzymes of the renin-angiotensin system and their inhibitors. Annu. Rev. Biochem., 51, 283-308


Database reference:
BindingDB: ID 50022905

ChEMBL: ID CHEMBL438636

ChemIdPlus: ID 75645-19-1

ChemSpider: ID 23122118

J-GLOBAL: ID 200907094652858052

Nikkaji: ID J2.195.478K

PepBank: Peptide PHPFHFFVYK

PubChem: CID 25077620

SureChEMBL: ID SCHEMBL10658727