BIOPEP-UWM: Report

ID 2757
Name rat NP-4 defensin
sequence
ACYCRIGACVSGERLTGACGLNGRIYRLCCR
Function:
Antimicrobial
 
Number of residues
31
Activity code
ab
Activity :
antibacterial
Chemical mass 3338.9524 Monoisotopic mass 3336.5656
EC50 :
0.00 µM


Bibliographic data:
Authors
Eisenhauer P. B., Harwig S. S., Szklarek D., Ganz T., Selsted M. E., Lehrer R. I.
Title
Purification and antimicrobial properties of three defensins from rat neutrophils. Infect. Immun., 57, 2021-2027, 1989
Year Source
1989 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: [H][C@@](C)(N)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)NCC(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CO)C(=O)NCC(=O)N[C@@]([H])(CCC(O)=O)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)NCC(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CS)C(=O)NCC(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(N)=O)C(=O)NCC(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CCCNC(N)=N)C(O)=O

InChI=1S/C136H229N47O39S6/c1-17-66(11)103(181-116(206)79(27-22-42-152-135(145)146)166-122(212)91(58-225)178-120(210)85(47-72-29-33-74(186)34-30-72)170-124(214)90(57-224)174-106(196)68(13)137)127(217)157-50-96(189)160-70(15)108(198)176-94(61-228)126(216)180-102(65(9)10)129(219)173-88(55-184)110(200)155-53-99(192)162-80(37-38-101(194)195)114(204)164-77(25-20-40-150-133(141)142)112(202)169-84(46-64(7)8)121(211)183-105(71(16)185)128(218)158-51-97(190)159-69(14)107(197)175-89(56-223)111(201)156-54-100(193)163-82(44-62(3)4)117(207)171-87(49-95(138)188)109(199)154-52-98(191)161-76(24-19-39-149-132(139)140)115(205)182-104(67(12)18-2)130(220)172-86(48-73-31-35-75(187)36-32-73)119(209)165-78(26-21-41-151-134(143)144)113(203)168-83(45-63(5)6)118(208)177-93(60-227)125(215)179-92(59-226)123(213)167-81(131(221)222)28-23-43-153-136(147)148/h29-36,62-71,76-94,102-105,184-187,223-228H,17-28,37-61,137H2,1-16H3,(H2,138,188)(H,154,199)(H,155,200)(H,156,201)(H,157,217)(H,158,218)(H,159,190)(H,160,189)(H,161,191)(H,162,192)(H,163,193)(H,164,204)(H,165,209)(H,166,212)(H,167,213)(H,168,203)(H,169,202)(H,170,214)(H,171,207)(H,172,220)(H,173,219)(H,174,196)(H,175,197)(H,176,198)(H,177,208)(H,178,210)(H,179,215)(H,180,216)(H,181,206)(H,182,205)(H,183,211)(H,194,195)(H,221,222)(H4,139,140,149)(H4,141,142,150)(H4,143,144,151)(H4,145,146,152)(H4,147,148,153)/t66-,67-,68-,69-,70-,71+,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,102-,103-,104-,105-/m0/s1


InChIKey=NZXKHIDHWJIZNQ-HVIYAMQPSA-N


Active agaist G(+), G(-) bacteria and fungi.


Database reference:
APD: ID AP00225

CAMP: ID CAMPSQ274

DBAASP: ID 871

PeptideDB: ID PEP13515

SATPdb: ID satpdb15057

YADAMP: ID 1275