BIOPEP-UWM: Report

ID 2758
Name rat NP-3 defensin
sequence
CSCRTSSCRFGERLSGACRLNGRIYRLCC
Function:
Antimicrobial
 
Number of residues
29
Activity code
ab
Activity :
antibacterial
Chemical mass 3271.8238 Monoisotopic mass 3269.4985
EC50 :
0.00 µM


Bibliographic data:
Authors
Eisenhauer P. B., Harwig S. S., Szklarek D., Ganz T., Selsted M. E., Lehrer R. I.
Title
Purification and antimicrobial properties of three defensins from rat neutrophils. Infect. Immun., 57, 2021-2027, 1989
Year Source
1989 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: [H][C@](N)(CS)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)NCC(=O)N[C@@]([H])(CCC(O)=O)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CO)C(=O)NCC(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(N)=O)C(=O)NCC(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CS)C(O)=O

InChI=1S/C130H220N48O39S6/c1-11-63(8)97(122(214)167-81(45-67-29-31-68(184)32-30-67)114(206)158-72(25-17-37-147-127(137)138)105(197)164-79(43-62(6)7)113(205)173-90(58-222)121(213)176-91(59-223)124(216)217)177-109(201)70(23-15-35-145-125(133)134)155-94(187)48-152-102(194)82(46-92(132)185)166-111(203)77(41-60(2)3)162-106(198)73(26-18-38-148-128(139)140)159-118(210)87(55-219)172-99(191)64(9)154-93(186)47-153-103(195)83(50-179)169-112(204)78(42-61(4)5)163-104(196)71(24-16-36-146-126(135)136)157-108(200)76(33-34-96(189)190)156-95(188)49-151-101(193)80(44-66-21-13-12-14-22-66)165-107(199)74(27-19-39-149-129(141)142)160-119(211)88(56-220)175-117(209)85(52-181)170-115(207)86(53-182)171-123(215)98(65(10)183)178-110(202)75(28-20-40-150-130(143)144)161-120(212)89(57-221)174-116(208)84(51-180)168-100(192)69(131)54-218/h12-14,21-22,29-32,60-65,69-91,97-98,179-184,218-223H,11,15-20,23-28,33-59,131H2,1-10H3,(H2,132,185)(H,151,193)(H,152,194)(H,153,195)(H,154,186)(H,155,187)(H,156,188)(H,157,200)(H,158,206)(H,159,210)(H,160,211)(H,161,212)(H,162,198)(H,163,196)(H,164,197)(H,165,199)(H,166,203)(H,167,214)(H,168,192)(H,169,204)(H,170,207)(H,171,215)(H,172,191)(H,173,205)(H,174,208)(H,175,209)(H,176,213)(H,177,201)(H,178,202)(H,189,190)(H,216,217)(H4,133,134,145)(H4,135,136,146)(H4,137,138,147)(H4,139,140,148)(H4,141,142,149)(H4,143,144,150)/t63-,64-,65+,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,97-,98-/m0/s1

InChIKey=ARWRGRPWQFDYEW-VPGMHBDZSA-N

Active agaist G(+), G(-) bacteria and fungi.


Database reference:
APD: ID AP00224

BaAMPs: ID NP_001073367

CAMP: ID CAMPSQ273

PeptideDB: ID PEP13514; PEP20015

SATPdb: ID satpdb15433

YADAMP: ID 1177