BIOPEP-UWM: Report

ID 2759
Name rat NP-2 defensin
sequence
VTCYCRSTRCGFRERLSGACGYRGRIYRLCCR
Function:
Antimicrobial
 
Number of residues
32
Activity code
ab
Activity :
antibacterial
Chemical mass 3766.4117 Monoisotopic mass 3763.7732
EC50 :
0.00 µM


Bibliographic data:
Authors
Eisenhauer P. B., Harwig S. S., Szklarek D., Ganz T., Selsted M. E., Lehrer R. I.
Title
Purification and antimicrobial properties of three defensins from rat neutrophils. Infect. Immun., 57, 2021-2027, 1989
Year Source
1989 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: [H][C@@](C)(NC(=O)CNC(=O)[C@]([H])(CO)NC(=O)[C@]([H])(CC(C)C)NC(=O)[C@]([H])(CCCNC(N)=N)NC(=O)[C@]([H])(CCC(O)=O)NC(=O)[C@]([H])(CCCNC(N)=N)NC(=O)[C@]([H])(Cc1ccccc1)NC(=O)CNC(=O)[C@]([H])(CS)NC(=O)[C@]([H])(CCCNC(N)=N)NC(=O)[C@@]([H])(NC(=O)[C@]([H])(CO)NC(=O)[C@]([H])(CCCNC(N)=N)NC(=O)[C@]([H])(CS)NC(=O)[C@]([H])(Cc1ccc(O)cc1)NC(=O)[C@]([H])(CS)NC(=O)[C@@]([H])(NC(=O)[C@@]([H])(N)C(C)C)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@]([H])(CS)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)NCC(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CCCNC(N)=N)C(O)=O

InChI=1S/C155H254N56O42S6/c1-12-77(8)117(144(249)200-102(61-84-38-44-87(218)45-39-84)136(241)192-92(30-20-52-177-152(165)166)127(232)198-98(57-75(4)5)133(238)205-109(72-258)142(247)207-108(71-257)140(245)196-96(147(252)253)33-23-55-180-155(171)172)209-131(236)89(27-17-49-174-149(159)160)186-112(220)63-181-121(226)88(26-16-48-173-148(157)158)189-134(239)100(59-82-34-40-85(216)41-35-82)188-114(222)64-183-123(228)105(68-254)203-120(225)78(9)185-111(219)62-182-122(227)103(66-212)201-132(237)97(56-74(2)3)197-126(231)91(29-19-51-176-151(163)164)190-130(235)95(46-47-115(223)224)194-125(230)90(28-18-50-175-150(161)162)191-135(240)99(58-81-24-14-13-15-25-81)187-113(221)65-184-124(229)106(69-255)204-129(234)94(32-22-54-179-154(169)170)195-145(250)118(79(10)214)210-138(243)104(67-213)202-128(233)93(31-21-53-178-153(167)168)193-139(244)107(70-256)206-137(242)101(60-83-36-42-86(217)43-37-83)199-141(246)110(73-259)208-146(251)119(80(11)215)211-143(248)116(156)76(6)7/h13-15,24-25,34-45,74-80,88-110,116-119,212-218,254-259H,12,16-23,26-33,46-73,156H2,1-11H3,(H,181,226)(H,182,227)(H,183,228)(H,184,229)(H,185,219)(H,186,220)(H,187,221)(H,188,222)(H,189,239)(H,190,235)(H,191,240)(H,192,241)(H,193,244)(H,194,230)(H,195,250)(H,196,245)(H,197,231)(H,198,232)(H,199,246)(H,200,249)(H,201,237)(H,202,233)(H,203,225)(H,204,234)(H,205,238)(H,206,242)(H,207,247)(H,208,251)(H,209,236)(H,210,243)(H,211,248)(H,223,224)(H,252,253)(H4,157,158,173)(H4,159,160,174)(H4,161,162,175)(H4,163,164,176)(H4,165,166,177)(H4,167,168,178)(H4,169,170,179)(H4,171,172,180)/t77-,78-,79+,80+,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,116-,117-,118-,119-/m0/s1

InChIKey=HLIWIEBMTXLEQW-ADZXXJEWSA-N



Active agaist G(+), G(-) bacteria and fungi.


Database reference:
APD: ID AP00223

CAMP: ID CAMPSQ272

PeptideDB: ID PEP13516

SATPdb: ID satpdb22241

YADAMP: ID 1301