BIOPEP-UWM: Report

ID 2760
Name rat NP-1 defensin
sequence
VTCYCRRTRCGFRERLSGACGYRGRIYRLCCR
Function:
Antimicrobial
 
Number of residues
32
Activity code
ab
Activity :
antibacterial
Chemical mass 3835.5198 Monoisotopic mass 3832.8422
EC50 :
0.00 µM


Bibliographic data:
Authors
Eisenhauer P. B., Harwig S. S., Szklarek D., Ganz T., Selsted M. E., Lehrer R. I.
Title
Purification and antimicrobial properties of three defensins from rat neutrophils. Infect. Immun., 57, 2021-2027, 1989
Year Source
1989 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: [H][C@@](C)(NC(=O)CNC(=O)[C@]([H])(CO)NC(=O)[C@]([H])(CC(C)C)NC(=O)[C@]([H])(CCCNC(N)=N)NC(=O)[C@]([H])(CCC(O)=O)NC(=O)[C@]([H])(CCCNC(N)=N)NC(=O)[C@]([H])(Cc1ccccc1)NC(=O)CNC(=O)[C@]([H])(CS)NC(=O)[C@]([H])(CCCNC(N)=N)NC(=O)[C@@]([H])(NC(=O)[C@]([H])(CCCNC(N)=N)NC(=O)[C@]([H])(CCCNC(N)=N)NC(=O)[C@]([H])(CS)NC(=O)[C@]([H])(Cc1ccc(O)cc1)NC(=O)[C@]([H])(CS)NC(=O)[C@@]([H])(NC(=O)[C@@]([H])(N)C(C)C)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@]([H])(CS)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)NCC(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CCCNC(N)=N)C(O)=O

InChI=1S/C158H261N59O41S6/c1-12-79(8)119(146(254)207-105(64-86-40-46-89(223)47-41-86)139(247)199-95(32-21-55-183-155(170)171)130(238)205-101(60-77(4)5)136(244)211-111(74-263)144(252)213-110(73-262)142(250)203-99(149(257)258)35-24-58-186-158(176)177)215-133(241)91(28-17-51-179-151(162)163)192-114(225)66-187-123(231)90(27-16-50-178-150(160)161)195-137(245)103(62-84-36-42-87(221)43-37-84)194-116(227)67-189-125(233)107(70-259)209-122(230)80(9)191-113(224)65-188-124(232)106(69-218)208-135(243)100(59-76(2)3)204-129(237)94(31-20-54-182-154(168)169)196-132(240)98(48-49-117(228)229)201-128(236)92(29-18-52-180-152(164)165)198-138(246)102(61-83-25-14-13-15-26-83)193-115(226)68-190-126(234)108(71-260)210-131(239)96(33-22-56-184-156(172)173)202-147(255)120(81(10)219)216-134(242)97(34-23-57-185-157(174)175)197-127(235)93(30-19-53-181-153(166)167)200-141(249)109(72-261)212-140(248)104(63-85-38-44-88(222)45-39-85)206-143(251)112(75-264)214-148(256)121(82(11)220)217-145(253)118(159)78(6)7/h13-15,25-26,36-47,76-82,90-112,118-121,218-223,259-264H,12,16-24,27-35,48-75,159H2,1-11H3,(H,187,231)(H,188,232)(H,189,233)(H,190,234)(H,191,224)(H,192,225)(H,193,226)(H,194,227)(H,195,245)(H,196,240)(H,197,235)(H,198,246)(H,199,247)(H,200,249)(H,201,236)(H,202,255)(H,203,250)(H,204,237)(H,205,238)(H,206,251)(H,207,254)(H,208,243)(H,209,230)(H,210,239)(H,211,244)(H,212,248)(H,213,252)(H,214,256)(H,215,241)(H,216,242)(H,217,253)(H,228,229)(H,257,258)(H4,160,161,178)(H4,162,163,179)(H4,164,165,180)(H4,166,167,181)(H4,168,169,182)(H4,170,171,183)(H4,172,173,184)(H4,174,175,185)(H4,176,177,186)/t79-,80-,81+,82+,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,118-,119-,120-,121-/m0/s1

InChIKey=QKSPCDQNZNUYCH-WCXBLLLZSA-N



Active agaist G(+), G(-) bacteria and fungi.


Database reference:
APD: ID AP00222

CAMP: ID CAMPSQ487

DBAASP: ID 11174

PeptideDB: ID PEP13517

SATPdb: ID satpdb16476