BIOPEP-UWM: Report

ID 2762
Name rabbit NP-5 defesin
sequence
VFCTCRGFLCGSGERASGSCTINGVRHTLCCRR
Function:
Antimicrobial
 
Number of residues
33
Activity code
ab
Activity :
antibacterial
Chemical mass 3551.1149 Monoisotopic mass 3548.6200
EC50 :
0.00 µM


Bibliographic data:
Authors
Selsted M. E., Brown D. M, DeLange R. J., Harwig S. S., Lehrer R. I.
Title
Primary structures of six antimicrobial peptides of rabbit peritoneal neutrophils. J. Biol. Chem., 260, 4579-4584, 1985
Year Source
1985 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: [H][C@@](C)(NC(=O)[C@]([H])(CCCNC(N)=N)NC(=O)[C@]([H])(CCC(O)=O)NC(=O)CNC(=O)[C@]([H])(CO)NC(=O)CNC(=O)[C@]([H])(CS)NC(=O)[C@]([H])(CC(C)C)NC(=O)[C@]([H])(Cc1ccccc1)NC(=O)CNC(=O)[C@]([H])(CCCNC(N)=N)NC(=O)[C@]([H])(CS)NC(=O)[C@@]([H])(NC(=O)[C@]([H])(CS)NC(=O)[C@]([H])(Cc1ccccc1)NC(=O)[C@@]([H])(N)C(C)C)[C@@H](C)O)C(=O)N[C@@]([H])(CO)C(=O)NCC(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(CC(N)=O)C(=O)NCC(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(CC1=CN=CN1)C(=O)N[C@@]([H])(C(C)O)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(CCCNC(N)=N)C(O)=O

InChI=1S/C143H237N51O43S6/c1-15-69(10)107(134(232)182-88(48-98(144)201)113(211)163-54-103(206)190-106(68(8)9)133(231)176-80(34-25-41-160-142(152)153)119(217)179-87(47-76-49-156-64-167-76)125(223)192-108(71(12)198)135(233)181-84(44-66(4)5)122(220)185-94(60-240)129(227)188-93(59-239)127(225)175-79(33-24-40-159-141(150)151)118(216)177-82(138(236)237)35-26-42-161-143(154)155)191-137(235)110(73(14)200)194-131(229)97(63-243)187-126(224)91(57-197)172-102(205)52-165-115(213)90(56-196)183-111(209)70(11)168-117(215)78(32-23-39-158-140(148)149)174-120(218)81(36-37-104(207)208)169-99(202)50-164-114(212)89(55-195)171-101(204)53-166-116(214)92(58-238)184-121(219)83(43-65(2)3)178-123(221)85(45-74-27-18-16-19-28-74)170-100(203)51-162-112(210)77(31-22-38-157-139(146)147)173-128(226)95(61-241)189-136(234)109(72(13)199)193-130(228)96(62-242)186-124(222)86(46-75-29-20-17-21-30-75)180-132(230)105(145)67(6)7/h16-21,27-30,49,64-73,77-97,105-110,195-200,238-243H,15,22-26,31-48,50-63,145H2,1-14H3,(H2,144,201)(H,156,167)(H,162,210)(H,163,211)(H,164,212)(H,165,213)(H,166,214)(H,168,215)(H,169,202)(H,170,203)(H,171,204)(H,172,205)(H,173,226)(H,174,218)(H,175,225)(H,176,231)(H,177,216)(H,178,221)(H,179,217)(H,180,230)(H,181,233)(H,182,232)(H,183,209)(H,184,219)(H,185,220)(H,186,222)(H,187,224)(H,188,227)(H,189,234)(H,190,206)(H,191,235)(H,192,223)(H,193,228)(H,194,229)(H,207,208)(H,236,237)(H4,146,147,157)(H4,148,149,158)(H4,150,151,159)(H4,152,153,160)(H4,154,155,161)/t69-,70-,71+,72+,73+,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,105-,106-,107-,108-,109-,110-/m0/s1

InChIKey=CLHVBTRFOSBHPJ-YQYBAXGXSA-N

Active agaist G(+), G(-) bacteria and fungi.


Database reference:
APD: ID AP00314

CAMP: ID CAMPSQ1619

PeptideDB: ID PEP03713

SATPdb: ID satpdb26820