BIOPEP-UWM: Report

ID 2764
Name rabbit NP-3B defensin
sequence
GRCVCRKQLLCSYRERRIGDCKIRGVRFPFCCPR
Function:
Antibacterial
 
Number of residues
34
Activity code
ab
Activity :
antibacterial
Chemical mass 4075.9036 Monoisotopic mass 4073.0617
EC50 :
0.00 µM


Bibliographic data:
Authors
Selsted M. E., Brown D. M, DeLange R. J., Harwig S. S., Lehrer R. I.
Title
Primary structures of six antimicrobial peptides of rabbit peritoneal neutrophils. J. Biol. Chem., 260, 4579-4584, 1985
Year Source
1985 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: [H][C@@](CO)(NC(=O)[C@]([H])(CS)NC(=O)[C@]([H])(CC(C)C)NC(=O)[C@]([H])(CC(C)C)NC(=O)[C@]([H])(CCC(N)=O)NC(=O)[C@]([H])(CCCCN)NC(=O)[C@]([H])(CCCNC(N)=N)NC(=O)[C@]([H])(CS)NC(=O)[C@@]([H])(NC(=O)[C@]([H])(CS)NC(=O)[C@]([H])(CCCNC(N)=N)NC(=O)CN)C(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(CCC(O)=O)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)NCC(=O)N[C@@]([H])(CC(O)=O)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)NCC(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CS)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCCNC(N)=N)C(O)=O

InChI=1S/C143H238N54O44S6/c1-64(2)43-82(120(223)188-93(59-244)128(231)191-92(58-243)126(229)177-77(31-21-39-161-140(150)151)116(219)179-81(137(240)241)34-24-42-164-143(156)157)182-134(237)106(69(10)202)195-122(225)85(46-74-48-158-63-169-74)181-118(221)79(33-23-41-163-142(154)155)178-132(235)104(66(5)6)193-101(209)52-166-111(214)86(47-97(144)205)183-133(236)105(67(7)8)194-136(239)108(71(12)204)197-130(233)95(61-246)189-123(226)88(54-199)173-100(208)51-167-112(215)87(53-198)184-109(212)68(9)170-114(217)75(29-19-37-159-138(146)147)174-119(222)80(35-36-102(210)211)171-98(206)49-165-110(213)83(44-72-25-15-13-16-26-72)172-99(207)50-168-113(216)91(57-242)187-124(227)89(55-200)185-121(224)84(45-73-27-17-14-18-28-73)180-117(220)78(32-22-40-162-141(152)153)175-115(218)76(30-20-38-160-139(148)149)176-127(230)94(60-245)192-135(238)107(70(11)203)196-129(232)96(62-247)190-125(228)90(56-201)186-131(234)103(145)65(3)4/h13-18,25-28,48,63-71,75-96,103-108,198-204,242-247H,19-24,29-47,49-62,145H2,1-12H3,(H2,144,205)(H,158,169)(H,165,213)(H,166,214)(H,167,215)(H,168,216)(H,170,217)(H,171,206)(H,172,207)(H,173,208)(H,174,222)(H,175,218)(H,176,230)(H,177,229)(H,178,235)(H,179,219)(H,180,220)(H,181,221)(H,182,237)(H,183,236)(H,184,212)(H,185,224)(H,186,234)(H,187,227)(H,188,223)(H,189,226)(H,190,228)(H,191,231)(H,192,238)(H,193,209)(H,194,239)(H,195,225)(H,196,232)(H,197,233)(H,210,211)(H,240,241)(H4,146,147,159)(H4,148,149,160)(H4,150,151,161)(H4,152,153,162)(H4,154,155,163)(H4,156,157,164)/t68-,69+,70+,71+,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,103-,104-,105-,106-,107-,108-/m0/s1

InChIKey=SPBQQULUYYSECI-JPPUHRGBSA-N



Active agaist G(+), G(-) bacteria and fungi.


Database reference:
APD: ID AP00186

CAMP: ID CAMPSQ1621

PeptideDB: ID PEP03715

SATPdb: ID satpdb14068