BIOPEP-UWM: Report

ID 2765
Name rabbit defensin NP-3A
sequence
GICACRRRFCPNSERFSGYCRVNGARYVRCCSRR
Function:
Antibacterial
 
Number of residues
34
Activity code
ab
Activity :
antibacterial
Chemical mass 4003.6299 Monoisotopic mass 4000.8705
EC50 :
0.00 µM


Bibliographic data:
Authors
Selsted M. E., Brown D. M, DeLange R. J., Harwig S. S., Lehrer R. I.
Title
Primary structures of six antimicrobial peptides of rabbit peritoneal neutrophils. J. Biol. Chem., 260, 4579-4584, 1985
Year Source
1985 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: [H][C@@](C)(NC(=O)CNC(=O)[C@]([H])(CC(N)=O)NC(=O)[C@@]([H])(NC(=O)[C@]([H])(CCCNC(N)=N)NC(=O)[C@]([H])(CS)NC(=O)[C@]([H])(Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@]([H])(CO)NC(=O)[C@]([H])(Cc1ccccc1)NC(=O)[C@]([H])(CCCNC(N)=N)NC(=O)[C@]([H])(CCC(O)=O)NC(=O)[C@]([H])(CO)NC(=O)[C@]([H])(CC(N)=O)NC(=O)[C@]1([H])CCCN1C(=O)[C@]([H])(CS)NC(=O)[C@]([H])(Cc1ccccc1)NC(=O)[C@]([H])(CCCNC(N)=N)NC(=O)[C@]([H])(CCCNC(N)=N)NC(=O)[C@]([H])(CCCNC(N)=N)NC(=O)[C@]([H])(CS)NC(=O)[C@]([H])(C)NC(=O)[C@]([H])(CS)NC(=O)[C@@]([H])(NC(=O)CN)[C@@H](C)CC)C(C)C)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(CCCNC(N)=N)C(O)=O

InChI=1S/C163H265N63O44S6/c1-9-80(6)123(223-117(234)66-164)152(267)221-108(72-271)144(259)197-82(8)125(240)217-109(73-272)145(260)204-91(32-18-52-187-157(171)172)129(244)200-90(31-17-51-186-156(169)170)128(243)201-93(34-20-54-189-159(175)176)132(247)210-101(61-84-28-14-11-15-29-84)139(254)222-113(77-276)153(268)226-59-25-39-114(226)149(264)212-104(65-116(166)233)140(255)215-106(70-228)143(258)206-97(48-49-120(237)238)135(250)202-94(35-21-55-190-160(177)178)133(248)209-100(60-83-26-12-10-13-27-83)138(253)214-105(69-227)127(242)195-68-119(236)198-99(62-85-40-44-87(230)45-41-85)137(252)219-110(74-273)146(261)205-96(37-23-57-192-162(181)182)136(251)224-122(79(4)5)151(266)213-103(64-115(165)232)126(241)194-67-118(235)196-81(7)124(239)199-89(30-16-50-185-155(167)168)131(246)211-102(63-86-42-46-88(231)47-43-86)141(256)225-121(78(2)3)150(265)207-95(36-22-56-191-161(179)180)134(249)218-112(76-275)148(263)220-111(75-274)147(262)216-107(71-229)142(257)203-92(33-19-53-188-158(173)174)130(245)208-98(154(269)270)38-24-58-193-163(183)184/h10-15,26-29,40-47,78-82,89-114,121-123,227-231,271-276H,9,16-25,30-39,48-77,164H2,1-8H3,(H2,165,232)(H2,166,233)(H,194,241)(H,195,242)(H,196,235)(H,197,259)(H,198,236)(H,199,239)(H,200,244)(H,201,243)(H,202,250)(H,203,257)(H,204,260)(H,205,261)(H,206,258)(H,207,265)(H,208,245)(H,209,248)(H,210,247)(H,211,246)(H,212,264)(H,213,266)(H,214,253)(H,215,255)(H,216,262)(H,217,240)(H,218,249)(H,219,252)(H,220,263)(H,221,267)(H,222,254)(H,223,234)(H,224,251)(H,225,256)(H,237,238)(H,269,270)(H4,167,168,185)(H4,169,170,186)(H4,171,172,187)(H4,173,174,188)(H4,175,176,189)(H4,177,178,190)(H4,179,180,191)(H4,181,182,192)(H4,183,184,193)/t80-,81-,82-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,121-,122-,123-/m0/s1

InChIKey=WAPXALUOWCTJOV-ZEXSPGRCSA-N



Active agaist G(+), G(-) bacteria and fungi.


Database reference:
APD: ID AP00217

PeptideDB: ID PEP03716

SATPdb: ID satpdb15137