BIOPEP-UWM: Report

ID 2766
Name rabbit defensin NP-2
sequence
VVCACRRALCLPLERRAAGFCRIRGRIHPLCCRR
Function:
Antibacterial
 
Number of residues
34
Activity code
ab
Activity :
antibacterial
Chemical mass 3925.8186 Monoisotopic mass 3923.0778
EC50 :
0.00 µM


Bibliographic data:
Authors
Selsted M. E., Brown D. M, DeLange R. J., Harwig S. S., Lehrer R. I.
Title
Primary structures of six antimicrobial peptides of rabbit peritoneal neutrophils. J. Biol. Chem., 260, 4579-4584, 1985
Year Source
1985 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: [H][C@@](C)(NC(=O)[C@]([H])(C)NC(=O)[C@]([H])(CCCNC(N)=N)NC(=O)[C@]([H])(CCCNC(N)=N)NC(=O)[C@]([H])(CCC(O)=O)NC(=O)[C@]([H])(CC(C)C)NC(=O)[C@]1([H])CCCN1C(=O)[C@]([H])(CC(C)C)NC(=O)[C@]([H])(CS)NC(=O)[C@]([H])(CC(C)C)NC(=O)[C@]([H])(C)NC(=O)[C@]([H])(CCCNC(N)=N)NC(=O)[C@]([H])(CCCNC(N)=N)NC(=O)[C@]([H])(CS)NC(=O)[C@]([H])(C)NC(=O)[C@]([H])(CS)NC(=O)[C@@]([H])(NC(=O)[C@@]([H])(N)C(C)C)C(C)C)C(=O)NCC(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)NCC(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(CC1=CN=CN1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(CCCNC(N)=N)C(O)=O

InChI=1S/C164H287N63O37S6/c1-21-85(15)122(151(259)210-93(39-26-52-185-156(166)167)128(236)195-71-117(228)201-94(40-27-53-186-157(168)169)135(243)224-123(86(16)22-2)152(260)216-108(68-92-69-184-78-196-92)154(262)227-62-36-49-116(227)148(256)214-105(65-81(7)8)139(247)219-114(77-270)146(254)221-112(75-268)144(252)207-99(45-32-58-191-162(178)179)133(241)211-102(155(263)264)47-34-60-193-164(182)183)225-136(244)100(46-33-59-192-163(180)181)208-143(251)111(74-267)220-140(248)106(67-91-37-24-23-25-38-91)202-118(229)70-194-124(232)87(17)197-125(233)88(18)198-129(237)95(41-28-54-187-158(170)171)203-131(239)97(43-30-56-189-160(174)175)205-134(242)101(50-51-119(230)231)209-137(245)104(64-80(5)6)213-147(255)115-48-35-61-226(115)153(261)107(66-82(9)10)215-145(253)113(76-269)218-138(246)103(63-79(3)4)212-126(234)89(19)199-130(238)96(42-29-55-188-159(172)173)204-132(240)98(44-31-57-190-161(176)177)206-142(250)110(73-266)217-127(235)90(20)200-141(249)109(72-265)222-150(258)121(84(13)14)223-149(257)120(165)83(11)12/h23-25,37-38,69,78-90,93-116,120-123,265-270H,21-22,26-36,39-68,70-77,165H2,1-20H3,(H,184,196)(H,194,232)(H,195,236)(H,197,233)(H,198,237)(H,199,238)(H,200,249)(H,201,228)(H,202,229)(H,203,239)(H,204,240)(H,205,242)(H,206,250)(H,207,252)(H,208,251)(H,209,245)(H,210,259)(H,211,241)(H,212,234)(H,213,255)(H,214,256)(H,215,253)(H,216,260)(H,217,235)(H,218,246)(H,219,247)(H,220,248)(H,221,254)(H,222,258)(H,223,257)(H,224,243)(H,225,244)(H,230,231)(H,263,264)(H4,166,167,185)(H4,168,169,186)(H4,170,171,187)(H4,172,173,188)(H4,174,175,189)(H4,176,177,190)(H4,178,179,191)(H4,180,181,192)(H4,182,183,193)/t85-,86-,87-,88-,89-,90-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,120-,121-,122-,123-/m0/s1

InChIKey=IZCKXAWXUAQUQY-YHCYZRNOSA-N


Active agaist G(+), G(-) bacteria and fungi.


Database reference: