BIOPEP-UWM: Report

ID 2767
Name rabbit defensin NP-1
sequence
VVCACRRALCLPRERRAGFCRIRGRIHPLCCRR
Function:
Antibacterial
 
Number of residues
33
Activity code
ab
Activity :
antibacterial
Chemical mass 3897.7689 Monoisotopic mass 3895.0579
EC50 :
0.00 µM


Bibliographic data:
Authors
Selsted M. E., Brown D. M, DeLange R. J., Harwig S. S., Lehrer R. I.
Title
Primary structures of six antimicrobial peptides of rabbit peritoneal neutrophils. J. Biol. Chem., 260, 4579-4584, 1985
Year Source
1985 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: [H][C@@](C)(NC(=O)[C@]([H])(CCCNC(N)=N)NC(=O)[C@]([H])(CCCNC(N)=N)NC(=O)[C@]([H])(CCC(O)=O)NC(=O)[C@]([H])(CCCNC(N)=N)NC(=O)[C@]1([H])CCCN1C(=O)[C@]([H])(CC(C)C)NC(=O)[C@]([H])(CS)NC(=O)[C@]([H])(CC(C)C)NC(=O)[C@]([H])(C)NC(=O)[C@]([H])(CCCNC(N)=N)NC(=O)[C@]([H])(CCCNC(N)=N)NC(=O)[C@]([H])(CS)NC(=O)[C@]([H])(C)NC(=O)[C@]([H])(CS)NC(=O)[C@@]([H])(NC(=O)[C@@]([H])(N)C(C)C)C(C)C)C(=O)NCC(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)NCC(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(CC1=CN=CN1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(CCCNC(N)=N)C(O)=O

InChI=1S/C161H283N65O36S6/c1-18-83(13)119(147(257)210-90(37-23-51-184-152(163)164)124(234)195-70-114(227)200-91(38-24-52-185-153(165)166)132(242)223-120(84(14)19-2)148(258)215-105(67-89-68-183-77-196-89)150(260)226-62-34-48-113(226)144(254)213-102(64-79(5)6)135(245)218-111(76-268)142(252)220-109(74-266)140(250)206-96(43-29-57-190-158(175)176)130(240)211-100(151(261)262)46-32-60-193-161(181)182)224-133(243)98(45-31-59-192-160(179)180)207-139(249)108(73-265)219-136(246)103(66-88-35-21-20-22-36-88)201-115(228)69-194-121(231)85(15)197-125(235)92(39-25-53-186-154(167)168)202-127(237)94(41-27-55-188-156(171)172)204-131(241)99(49-50-116(229)230)208-129(239)97(44-30-58-191-159(177)178)209-143(253)112-47-33-61-225(112)149(259)104(65-80(7)8)214-141(251)110(75-267)217-134(244)101(63-78(3)4)212-122(232)86(16)198-126(236)93(40-26-54-187-155(169)170)203-128(238)95(42-28-56-189-157(173)174)205-138(248)107(72-264)216-123(233)87(17)199-137(247)106(71-263)221-146(256)118(82(11)12)222-145(255)117(162)81(9)10/h20-22,35-36,68,77-87,90-113,117-120,263-268H,18-19,23-34,37-67,69-76,162H2,1-17H3,(H,183,196)(H,194,231)(H,195,234)(H,197,235)(H,198,236)(H,199,247)(H,200,227)(H,201,228)(H,202,237)(H,203,238)(H,204,241)(H,205,248)(H,206,250)(H,207,249)(H,208,239)(H,209,253)(H,210,257)(H,211,240)(H,212,232)(H,213,254)(H,214,251)(H,215,258)(H,216,233)(H,217,244)(H,218,245)(H,219,246)(H,220,252)(H,221,256)(H,222,255)(H,223,242)(H,224,243)(H,229,230)(H,261,262)(H4,163,164,184)(H4,165,166,185)(H4,167,168,186)(H4,169,170,187)(H4,171,172,188)(H4,173,174,189)(H4,175,176,190)(H4,177,178,191)(H4,179,180,192)(H4,181,182,193)/t83-,84-,85-,86-,87-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,117-,118-,119-,120-/m0/s1

InChIKey=DAMJAPQYXVKRQY-CCTNCFKYSA-N


Active agaist G(+), G(-) bacteria and fungi.


Database reference:
APD: ID AP00187

CAMP: ID CAMPSQ76

PeptideDB: ID PEP03212

SATPdb: ID satpdb17105