BIOPEP-UWM: Report

ID 2816
Name PEP inhibitor
sequence
GVQVETISPGDGRTFPK

Function:
Inhibitor of prolyl oligopeptidase (EC 3.4.21.26) (MEROPS ID: S09.001)
 
Number of residues
17
Activity code
am
Activity :
antiamnestic
Chemical mass 1787.9618 Monoisotopic mass 1786.9184
EC50 :
273.00 µM



Bibliographic data:
Authors
Ohmori T., Nakagami T., Tanaka H., Maruyama S.
Title
Isolation of propyl endopeptidase-inhibiting peptide from bovine brain. Biochem. Biophys. Res. Commun., 202 (2), 809-815, 1994
Year Source
1994 Journal



Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES:
[H][C@@](CCCCN)(NC(=O)[C@]1([H])CCCN1C(=O)[C@]([H])(Cc1ccccc1)NC(=O)[C@@]([H])(NC(=O)[C@]([H])(CCCNC(N)=N)NC(=O)CNC(=O)[C@]([H])(CC(O)=O)NC(=O)CNC(=O)[C@]1([H])CCCN1C(=O)[C@]([H])(CO)NC(=O)[C@@]([H])(NC(=O)[C@@]([H])(NC(=O)[C@]([H])(CCC(O)=O)NC(=O)[C@@]([H])(NC(=O)[C@]([H])(CCC(N)=O)NC(=O)[C@@]([H])(NC(=O)CN)C(C)C)C(C)C)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)O)C(O)=O

InChI=1S/C78H126N22O26/c1-9-40(6)61(96-74(122)63(42(8)103)98-67(115)46(25-27-57(108)109)90-71(119)60(39(4)5)95-66(114)45(24-26-53(81)104)89-70(118)59(38(2)3)94-54(105)34-80)72(120)93-50(37-101)76(124)99-30-16-22-51(99)68(116)86-36-56(107)88-48(33-58(110)111)64(112)85-35-55(106)87-44(21-15-29-84-78(82)83)65(113)97-62(41(7)102)73(121)92-49(32-43-18-11-10-12-19-43)75(123)100-31-17-23-52(100)69(117)91-47(77(125)126)20-13-14-28-79/h10-12,18-19,38-42,44-52,59-63,101-103H,9,13-17,20-37,79-80H2,1-8H3,(H2,81,104)(H,85,112)(H,86,116)(H,87,106)(H,88,107)(H,89,118)(H,90,119)(H,91,117)(H,92,121)(H,93,120)(H,94,105)(H,95,114)(H,96,122)(H,97,113)(H,98,115)(H,108,109)(H,110,111)(H,125,126)(H4,82,83,84)/t40-,41+,42+,44-,45-,46-,47-,48-,49-,50-,51-,52-,59-,60-,61-,62-,63-/m0/s1

InChIKey=DMLPNNRLNUKJSN-WQGYSKGBSA-N



Database reference: