BIOPEP-UWM: Report

ID 2823
Name PEP inhibitor
sequence
RYDWWPYGNLFGGHTFISP
Function:
Inhibitor of prolyl oligopeptidase (EC 3.4.21.26) (MEROPS ID: S09.001)
 
Number of residues
19
Activity code
am
Activity :
antiamnestic
Chemical mass 2313.5193 Monoisotopic mass 2312.0770
EC50 :
0.00 µM


Bibliographic data:
Authors
Kimura K., Kanou F., Yamashita Y., Yoshimoto T.
Title
Prolyl endopeptidase inhibitors derived from actinomycetes. Biosci. Biotech. Biochem., 61(10),1754-1756, 1997
Year Source
1997 Journal


Additional information:

BIOPEP-UWM database of bioactive peptides

SMILES:
[H][C@](N)(CCCNC(N)=N)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(O)=O)C(=O)N[C@@]([H])(CC1=CNC2=C1C=CC=C2)C(=O)N[C@@]([H])(CC1=CNC2=C1C=CC=C2)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@]([H])(CC(N)=O)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)NCC(=O)NCC(=O)N[C@@]([H])(CC1=CN=CN1)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(CO)C(=O)N1CCC[C@@]1([H])C(O)=O

InChI=1S/C113H145N27O27/c1-6-61(4)95(108(162)136-87(58-141)111(165)140-41-19-30-89(140)112(166)167)137-105(159)81(44-64-22-11-8-12-23-64)134-109(163)96(62(5)142)138-106(160)83(49-69-54-118-59-125-69)126-92(147)56-122-91(146)55-123-98(152)78(43-63-20-9-7-10-21-63)130-100(154)77(42-60(2)3)129-103(157)84(50-90(115)145)127-93(148)57-124-99(153)79(45-65-31-35-70(143)36-32-65)133-107(161)88-29-18-40-139(88)110(164)86(48-68-53-121-76-28-16-14-25-73(68)76)135-102(156)82(47-67-52-120-75-27-15-13-24-72(67)75)131-104(158)85(51-94(149)150)132-101(155)80(46-66-33-37-71(144)38-34-66)128-97(151)74(114)26-17-39-119-113(116)117/h7-16,20-25,27-28,31-38,52-54,59-62,74,77-89,95-96,120-121,141-144H,6,17-19,26,29-30,39-51,55-58,114H2,1-5H3,(H2,115,145)(H,118,125)(H,122,146)(H,123,152)(H,124,153)(H,126,147)(H,127,148)(H,128,151)(H,129,157)(H,130,154)(H,131,158)(H,132,155)(H,133,161)(H,134,163)(H,135,156)(H,136,162)(H,137,159)(H,138,160)(H,149,150)(H,166,167)(H4,116,117,119)/t61-,62+,74-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,95-,96-/m0/s1

InChIKey=GGFGRYTUGHQOQA-XQNJINGOSA-N


Database reference: