BIOPEP-UWM: Report

ID 2858
Name dynorphin A
sequence
YGGFLRRIRPKLKWDNQ
Function:
Opioid
 
Number of residues
17
Activity code
op
Activity :
opioid
Chemical mass 2147.4777 Monoisotopic mass 2146.1878
EC50 :
0.00 µM


Bibliographic data:
Authors
Goldstein A., Fischli W., Lowney L. I., Hunkapiller M., Hood L.
Title
Porcine pituitary dynorphin: Complete amino acid sequence of the biologically active heptadecapeptide. Proc. Natl Acad. Sci. USA, 78, 7219-7223, 1981
Year Source
1981 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES:
[H][C@](N)(Cc1ccc(O)cc1)C(=O)NCC(=O)NCC(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC1=CNC2=C1C=CC=C2)C(=O)N[C@@]([H])(CC(O)=O)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N[C@@]([H])(CCC(N)=O)C(O)=O

InChI=1S/C99H155N31O23/c1-7-55(6)81(129-86(142)66(28-18-40-112-98(107)108)118-83(139)65(27-17-39-111-97(105)106)120-88(144)70(44-54(4)5)125-89(145)71(46-56-21-9-8-10-22-56)117-79(135)52-115-78(134)51-116-82(138)61(102)45-57-31-33-59(131)34-32-57)94(150)122-67(29-19-41-113-99(109)110)95(151)130-42-20-30-75(130)93(149)121-64(26-14-16-38-101)85(141)124-69(43-53(2)3)87(143)119-63(25-13-15-37-100)84(140)126-72(47-58-50-114-62-24-12-11-23-60(58)62)90(146)128-74(49-80(136)137)92(148)127-73(48-77(104)133)91(147)123-68(96(152)153)35-36-76(103)132/h8-12,21-24,31-34,50,53-55,61,63-75,81,114,131H,7,13-20,25-30,35-49,51-52,100-102H2,1-6H3,(H2,103,132)(H2,104,133)(H,115,134)(H,116,138)(H,117,135)(H,118,139)(H,119,143)(H,120,144)(H,121,149)(H,122,150)(H,123,147)(H,124,141)(H,125,145)(H,126,140)(H,127,148)(H,128,146)(H,129,142)(H,136,137)(H,152,153)(H4,105,106,111)(H4,107,108,112)(H4,109,110,113)/t55-,61-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,81-/m0/s1

InChIKey=JMNJYGMAUMANNW-FIXZTSJVSA-N


Activator of Insulysin (EC 3.4.24.56) (MEROPS ID M16.002) according to the BRENDA database


Database reference:
BindingDB: ID 50010702

BRENDA: Ligand dynorphin A-17

ChEMBL: ID CHEMBL411557

ChemIDplus: ID 80448-90-4

ChemSpider: ID 17290383

CREST: Chemical JMNJYGMAUMANNW-FIXZTSJVSA-N

DSigDB: ID d4boss_783

EROP-Moscow: ID E00305

FDA SRS: ID 9M18T0TD14

J-GLOBAL: ID 200907014778287014

NeuroPep: ID NP04089; NP04109; NP04127; NP04154; NP04173

Nikkaji: ID J39.440H

PepBank: Peptide YGGFLRRIRPKLKWDNQ

PeptideDB: ID PEP02123; PEP02934; PEP02943; PEP03618; PEP13453; PEP17486;

PubChem: CID 91928823