BIOPEP-UWM: Report

ID 2879
Name opioid peptide Leu-enkephalin
sequence
YGGFL
Function:
opioid peptide Leu-enkephalin
 
Number of residues
5
Activity code
op1
Activity :
opioid agonist
Chemical mass 555.6212 Monoisotopic mass 555.2684
EC50 :
0.00 µM


Bibliographic data:
Authors
Hughes J., Smith T. W., Kosterlitz H. W., Fothergill L. A., Morgan B. A., Morris H. R.
Title
Identification of two related pentapeptides from the brain with potent opiate agonist activity. Nature, 258, 577-579, 1975
Year Source
1975 Journal


Additional information:

SMILES:
[H][C@](N)(Cc1ccc(O)cc1)C(=O)NCC(=O)NCC(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CC(C)C)C(O)=O

InChI=1S/C28H37N5O7/c1-17(2)12-23(28(39)40)33-27(38)22(14-18-6-4-3-5-7-18)32-25(36)16-30-24(35)15-31-26(37)21(29)13-19-8-10-20(34)11-9-19/h3-11,17,21-23,34H,12-16,29H2,1-2H3,(H,30,35)(H,31,37)(H,32,36)(H,33,38)(H,39,40)/t21-,22-,23-/m0/s1

InChIKey=URLZCHNOLZSCCA-VABKMULXSA-N


Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8122)
Activator of catalase (EC 1.11.1.6) according to the BRENDA database
Inhibitor of Aminopeptidase B (EC 3.4.11.6) (MEROPS ID: M01.014) according to the BRENDA database
Inhibitor of Dipeptidyl peptidase III (EC 3.4.14.4) (MEROPS ID: M49.001) according to the BIOPEP-UWM database of bioactive peptides (ID 9521); the BRENDA database
Inhibitor of Carboxypeptidase E (EC 3.4.17.10) (MEROPS ID: M14.005) according to the BRENDA database
Inhibitor of Neprilysin (EC 3.4.24.11) (MEROPS ID: M13.001) according to the BRENDA database
Inhibitor of Dactylysin (EC 3.4.24.60) (MEROPS ID: M9G.026) according to the BRENDA database
Inhibitor of Neprilysin-2 (EC 3.4.24.B14) (MEROPS ID: M13.008) according to the BRENDA database
Anti-osteoporosis peptide according to the ChEMBL database


Database reference:
ACToR: ID 59141-40-1

BindingDB: ID 50001465

BIOPEP-UWM database of bioactive peptides: ID 8122; 9521

Brainpeps: ID 30

BRENDA: Ligand Leu-enkephalin

ChEBI: ID 89656

ChEMBL: ID CHEMBL8234

ChemDB: ID 030267

ChemIDplus: ID 58822-25-6

ChemSpider: ID 406229

DSigDB: ID d4boss_797

EROP-Moscow: ID E00146

FDA SRS: ID RI01R707R6

HMDB: ID HMDB0001045

FooDB: ID FDB022389

J-GLOBAL: ID 200907075256978300

MMDB: ID MMDB138362

NeuroPep: ID NP04031; NP04091; NP04111; NP04129; NP04142; NP04156; NP04175; NP04194

Nikkaji: ID J247.065I

PepBank: peptide YGGFL

PEPLife: ID 2243; 2244; 2245; 2246; 2247; 2248; 2249; 2250; 2251; 2252; 2253; 2254; 2255; 2256; 2257; 2258; 2259; 2269; 2270; 2271; 2272; 2458; 2459; 2665; 2893; 3081; 3082; 3083; 3084; 3085; 3086; 3171; 3172

PeptideDB: ID PEP02118; PEP02915; PEP02921; PEP02929; PEP02938; PEP03465; PEP03613; PEP05060; PEP06088; PEP06217; PEP10160; PEP13448; PEP15525; PEP17481

PubChem: CID 461776

SATPdb: ID satpdb28835

SureChEMBL: ID SCHEMBL631959

ZINC: ID ZINC000014952116